Schistosome Vaccine Adjuvants in Preclinical and Clinical Research

Vaccines
Rachel StephensonIstvan Toth

Abstract

There is currently no vaccine available for human use for any parasitic infections, including the helminth disease, schistosomiasis. Despite many researchers working towards this goal, one of the focuses has been on identifying new antigenic targets. The bar to achieve protective efficacy in humans was set at a consistent induction of 40% protection or better by the World Health Organisation (WHO), and although this is a modest goal, it is yet to be reached with the six most promising schistosomiasis vaccine candidates (Sm28GST, IrV5, Sm14, paramyosin, TPI, and Sm23). Adjuvant selection has a large impact on the effectiveness of the vaccine, and the use of adjuvants to aid in the stimulation of the immune system is a critical step and a major variable affecting vaccine development. In addition to a comprehensive understanding of the immune system, level of protection and the desired immune response required, there is also a need for a standardised and effective adjuvant formulation. This review summarises the status of adjuvants that have been or are being employed in schistosomiasis vaccine development focusing on immunisation outcomes at preclinical and clinical stages.

References

Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J PearceA Sher
Apr 6, 1995·Nature·A M KriegD M Klinman
Jan 1, 1994·Biotherapy·A Nohria, R H Rubin
Feb 1, 1997·Vaccine·J C Cox, A R Coulter
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·G J WeinerA M Krieg
May 20, 1999·International Journal for Parasitology·D BoulangerA Capron
Nov 11, 1999·Parasitology Today·M Nyindo, I O Farah
Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F R Vogel
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M OkanoD A Harn
Oct 5, 2001·Memórias do Instituto Oswaldo Cruz·C R RamosM Tendler
Jul 3, 2002·Nature Reviews. Immunology·Edward J Pearce, Andrew S MacDonald
Aug 15, 2002·British Medical Bulletin·André CapronGilles Riveau
Dec 10, 2002·Memórias do Instituto Oswaldo Cruz·Allen W CheeverZilton A Andrade
May 15, 2003·Acta Tropica·Edward J Pearce
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy C PetersonThomas F Gajewski
Jun 24, 2003·The International Journal of Biochemistry & Cell Biology·Jinjiang FanPaul J Brindley
Nov 8, 2003·Vaccine·Mônica Magno VilarMiriam Tendler
Apr 15, 2004·Parasitology International·Donald P McManus, Paul B Bartley
Jun 5, 2004·Expert Review of Vaccines·Michael LebensJan Holmgren
Jun 19, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marie-Eve FortierGiamal N Luheshi
Oct 14, 2004·Immunology and Cell Biology·Nikolai Petrovsky, Julio César Aguilar
Mar 1, 2005·Trends in Parasitology·André CapronFrançois Trottein
May 4, 2005·Parasitology International·Geoffrey N Gobert, Donald P McManus
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah BuchanJason Rice
Sep 20, 2005·Acta Tropica·Zhong-Dao WuXin-Bing Yu
Sep 24, 2005·Parasite Immunology·S J JenkinsA P Mountford

❮ Previous
Next ❯

Citations

Jul 7, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jasdave S ChahalDaniel G Anderson
Apr 12, 2016·Biochimica Et Biophysica Acta. General Subjects·Rashika El RidiFederica Migliardo
Oct 8, 2016·Parasites & Vectors·Biniam Mathewos TebejeDonald P McManus
Feb 19, 2016·Parasites & Vectors·R Alan WilsonWilliam Castro-Borges

❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation
FCA

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

© 2021 Meta ULC. All rights reserved