Schistosomiasis in School Age Children in Sierra Leone After 6 Years of Mass Drug Administration With Praziquantel

Frontiers in Public Health
Yakuba M BahYaobi Zhang

Abstract

Historic data and baseline surveys showed schistosomiasis as highly/moderately endemic in 7 of 14 districts in Sierra Leone, justifying annual/biennial mass drug administration (MDA) with praziquantel. MDA commenced in 2009 and reported treatment coverage had been above the World Health Organization recommended 75% of target population. Assessment in 2012 showed significant reduction in infection. In 2016, another national school-based survey was conducted to evaluate the progress. Two schools from each category (high, moderate or low) of endemic communities in each MDA district and five schools in non-MDA districts were selected. Fifty children (25 boys and 25 girls) aged 9-14 years were randomly selected per school. Parasitological examination of 1,980 stool and 1,382 urine samples were conducted. Overall Schistosoma mansoni prevalence in the seven MDA districts decreased to 20.4% (95% CI: 18.7-22.3%) in 2016 from 42.2% (95% CI: 39.8-44.5%) at baseline (p < 0.0001). Mean overall S. mansoni intensity of infection reduced to 52.8 epg (95% CI: 43.2-62.4 epg) in 2016 from 100.5 epg (95% CI: 88.7-112.3 epg) at baseline (p < 0.001). The prevalence of Schistosoma haematobium in the five MDA districts that had baseline prevalence dat...Continue Reading

References

Apr 1, 1989·Annals of Tropical Medicine and Parasitology·P T WhiteS V Amara
Mar 1, 1985·The American Journal of Tropical Medicine and Hygiene·L S StephensonM L Oduori
Jun 22, 2005·Trends in Parasitology·Jennifer F FriedmanStephen T McGarvey
May 19, 2011·BMJ : British Medical Journal·Darren J GrayDonald P McManus
Sep 19, 2012·The American Journal of Tropical Medicine and Hygiene·Sara E ButlerDiana M S Karanja
Oct 4, 2012·The American Journal of Tropical Medicine and Hygiene·Jennifer A DownsDaniel W Fitzgerald
Jul 9, 2013·Handbook of Clinical Neurology·Christina Marie Coyle
Aug 13, 2013·PLoS Neglected Tropical Diseases·Martial L Ndeffo MbahAlison P Galvani
Apr 5, 2014·Lancet·Daniel G ColleyCharles H King
Jun 26, 2014·Journal of the Egyptian Society of Parasitology·Ahmad A OthmanAhmed A Ganna
Feb 1, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Abiola Fatimah AdenowoAbidemi Paul Kappo
Jan 16, 2016·Bulletin of the World Health Organization·Hamado OuedraogoYaobi Zhang
Jan 18, 2017·Trends in Parasitology·Loc Le, Michael H Hsieh
Aug 5, 2017·PLoS Neglected Tropical Diseases·Jennifer R HerricksChristopher J L Murray
Oct 27, 2017·PLoS Neglected Tropical Diseases·Clive Shiff

❮ Previous
Next ❯

Citations

Jun 6, 2020·South African Family Practice : Official Journal of the South African Academy of Family Practice/Primary Care·Ramprakash Kaswa, Marietjie De Villiers
Aug 30, 2019·Nature·Tien Nguyen
Jan 1, 2021·BMC Medical Informatics and Decision Making·Joseph TassoneSalimur Choudhury
Feb 25, 2021·Nature Reviews. Neurology·William L MackenRobert D S Pitceathly

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA

Software Mentioned

Complex
QGIS
excel
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.