Schizencephaly revisited

Neuroradiology
Paul D Griffiths

Abstract

In this paper, I will report the range of appearances of schizencephaly in children and fetuses by reviewing a 10-year experience from a single centre and detail classification systems for the different forms of schizencephaly. This will lead to re-assessment of possible aetiological and mechanistic causes of schizencephaly. All cases of pediatric and fetal schizencephaly were located on the local database between 2007 and 2016 inclusive. The studies were reviewed for the presence, location and type of schizencephaly, as well as the state of the (cavum) septum pellucidum, the location of the fornices and the presence of other brain abnormalities. The review included 21 children and 11 fetuses with schizencephaly. Schizencephaly (type 1) was found in 9% of children but no fetuses, schizencephaly (type 2) was present in 67% of the pediatric cases and in 45% of fetuses, whilst schizencephaly (type 3) was present in approximately 24% of children and 55% of fetuses. Other brain abnormalities were found in 67% of children and 55% of fetuses. I have proposed a new system for classifying schizencephaly that takes into account all definitions of the abnormality in the literature. Using that approach, I have described the appearances and...Continue Reading

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Citations

Jan 19, 2019·Neuroradiology·Rüdiger von Kummer
Nov 21, 2019·Journal of Inherited Metabolic Disease·Stina SchillerJutta Gärtner
Jun 4, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D SunilkumarS Sabarish
Aug 12, 2020·Brain : a Journal of Neurology·Mariasavina SeverinoAndrea Rossi
Jul 25, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sarah W CaterSujata V Ghate
Nov 12, 2019·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·P D Griffiths, D Jarvis
Oct 7, 2020·Clinical Radiology·D J WardP D Griffiths
Aug 10, 2021·Neuro-ophthalmology·Benyam KindeJonathan C Horton
Aug 15, 2021·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Tally Lerman-SagieGustavo Malinger

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