Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models

Frontiers in Psychiatry
James N Samsom, Albert H C Wong

Abstract

Patients with schizophrenia are at an increased risk for the development of depression. Overlap in the symptoms and genetic risk factors between the two disorders suggests a common etiological mechanism may underlie the presentation of comorbid depression in schizophrenia. Understanding these shared mechanisms will be important in informing the development of new treatments. Rodent models are powerful tools for understanding gene function as it relates to behavior. Examining rodent models relevant to both schizophrenia and depression reveals a number of common mechanisms. Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate Delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1, and its interacting partners, reelin, maternal immune activation, and social isolation. Neurotransmission, brain connectivity, the immune system, the environment, and metabolism emerge as potential common mechanisms linking these models and potentially explaining comorbid depression in schizophrenia.

References

Jan 1, 1977·Physiology & Behavior·B J Sahakian, T W Robbins
Feb 1, 1976·Archives of General Psychiatry·T H McGlashan, W T Carpenter
Dec 1, 1991·Archives of General Psychiatry·J JohnsonM M Weissman
Jan 1, 1989·Schizophrenia Bulletin·M McGue, I I Gottesman
Feb 1, 1987·The Journal of Nervous and Mental Disease·E S ProsserL E Hollister
Dec 1, 1988·The American Journal of Psychiatry·S G SirisE Casey
Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
Jan 1, 1984·Psychopharmacology·P Willner
May 1, 1984·Journal of Neuroscience Methods·R Morris
Aug 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·D A Johnson
May 1, 1995·Psychological Medicine·R ElliottB J Sahakian
Jan 1, 1994·Schizophrenia Bulletin·M HarrowJ Marengo
Feb 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L S WilkinsonT W Robbins
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Aug 1, 1995·Medical Hypotheses·R S Smith, M Maes
May 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A K MalhotraA Breier
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·N Wongwitdecha, C A Marsden
Dec 6, 1996·The Journal of Biological Chemistry·S KurodaU Kikkawa
Nov 1, 1996·Psychiatry Research·M W HautS M Bloomfield
Aug 1, 1997·Physiology & Behavior·F S HallT W Robbins
Aug 1, 1997·Physiology & Behavior·F S HallT W Robbins
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J A GogosM Karayiorgou
Jun 11, 1999·Neuroreport·P TuetingC Pesold
Sep 10, 1999·Acta Psychiatrica Scandinavica·H HäfnerW an der Heiden
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
Mar 16, 2000·The EMBO Journal·S G KernieL F Parada
Sep 29, 2000·The American Journal of Psychiatry·P F SullivanK S Kendler

❮ Previous
Next ❯

Citations

Nov 26, 2015·Neuroscience and Biobehavioral Reviews·Juan F Codocedo, Nibaldo C Inestrosa
Mar 5, 2016·Nature Reviews. Drug Discovery·Mark J MillanDaniel Weinberger
Nov 5, 2016·Nature Reviews. Neuroscience·Yun Kyung Park, Yukiko Goda
Jul 12, 2017·Molecular Psychiatry·N BenamerL Tricoire
Jul 25, 2020·Translational Psychiatry·Jia XuXiaochuan Wang
Aug 22, 2018·Frontiers in Pharmacology·Sébastien MorenoJean Mazella
Jun 26, 2020·Frontiers in Psychiatry·Christina D Kang-YiC Neill Epperson
Jul 31, 2020·The European Journal of Neuroscience·Andrew Isaac MesoPeter J Hills
Jul 2, 2019·The Journal of Nervous and Mental Disease·Jianjie HuangSuling Chen
May 11, 2021·Frontiers in Behavioral Neuroscience·Nadine RittwegerKlaus Funke
Aug 6, 2021·Applied Neuropsychology. Adult·Ana B VivasPaul G Overton

❮ Previous
Next ❯

Methods Mentioned

BETA
gene trap
nucleotide exchange
light sheet microscopy
gene knockdown

Software Mentioned

MIA
Disc1

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Neuroscience
Fadel Tissir, André M Goffinet
The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Damon T Page
Current Topics in Microbiology and Immunology
L W Jurata, G N Gill
© 2021 Meta ULC. All rights reserved