Schizophrenia and platelet monoamine oxidase: research strategies

Schizophrenia Bulletin
M S BuchsbaumD L Murphy

Abstract

The most widely replicated neurochemical finding in schizophrenia is that of lower levels of monoamine oxidase (MAO) in the platelets of chronic schizophrenics than in normal controls. Yet, the etiological role of MAO in schizophrenia remains to be demonstrated. The incidence of low MAO in other psychiatric disorders, effects of diet, hormones and drugs, and relationships of platelet MAO to brain levels and genetic mechanisms remain unclear. This article examines factors which make any biological indicator suitable for use as a diagnostic test for schizophrenia and inquires into the methodological pitfalls and unexamined assumptions of various research strategies which use this measure.

Citations

Jan 1, 1987·European Archives of Psychiatry and Neurological Sciences·A FleissnerB Fuisting
Feb 1, 1982·Behavior Genetics·J E Pintar, X O Breakefield
Sep 1, 1992·Schizophrenia Research·M A Marcolin, J M Davis
Jan 1, 1981·Archiv für Psychiatrie und Nervenkrankheiten·P ProppingH Beckmann
Sep 15, 2009·L'Encéphale·A AutiéD Januel
Feb 1, 1983·Acta Psychiatrica Scandinavica·M AratóZ Kulcsár

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