Schizophrenia and risk of dementia: a meta-analysis study

Neuropsychiatric Disease and Treatment
Laisheng Cai, Jingwei Huang

Abstract

Evidence suggests that schizophrenia may be associated with an increased risk of dementia, but results from prior studies have been inconsistent. This study aimed to estimate the relationship between schizophrenia and incident dementia using a quantitative meta-analysis. Several databases were used to gather relevant information, including PubMed, Embase, and Web of Science, with the publication date of articles limited up to December 23, 2017. All studies reported a multivariate-adjusted estimate, represented as relative risk (RR) with 95% confidence intervals (CIs), for the association between schizophrenia and risk of dementia incidence. Pooled RRs were calculated using a random-effects model. Six studies met our inclusion criteria for this meta-analysis, which included 206,694 cases of dementia and 5,063,316 participants. All individuals were without dementia at baseline. Overall, the quantitative meta-analysis suggested that subjects with schizophrenia were associated with a significantly greater risk of dementia incidence (RR 2.29; 95% CI 1.35-3.88) than those without. The results of this meta-analysis indicate that individuals with schizophrenia may have an increased risk for the development of dementia. Future studies s...Continue Reading

Citations

Jun 11, 2020·Psychiatric Services : a Journal of the American Psychiatric Association·Eileen P AhearnJohn F McCarthy
Sep 6, 2020·Journal of Molecular Neuroscience : MN·Sadiatul MarzanMohammad Safiqul Islam
Aug 11, 2019·International Journal of Environmental Research and Public Health·Chih-Ching LiuSusan C Hu
May 18, 2020·European Archives of Psychiatry and Clinical Neuroscience·Christina J HeroldJohannes Schröder
Feb 12, 2019·Journal of Alzheimer's Disease : JAD·Yoshiki TakamatsuMakoto Hashimoto
Oct 11, 2019·Cognitive Neuropsychiatry·Quintí Foguet-BoreuJordina Muñoz Pradós
Oct 31, 2019·Therapeutic Advances in Psychopharmacology·Rajesh R TampiDeena J Tampi
Jul 19, 2020·Schizophrenia Bulletin·Peter KochunovL Elliot Hong
Oct 27, 2020·International Journal of Geriatric Psychiatry·Liang-Nan ZengYu-Tao Xiang
Jan 13, 2021·Schizophrenia Research·Shiva Shanker Reddy MukkuSanjeev Jain
Feb 14, 2021·Clinical Gerontologist·Sarah DobbinsHeather Leutwyler
Mar 13, 2021·The Clinical Neuropsychologist·Bern G LeeMonique Wilson
Mar 6, 2021·Schizophrenia Research·Jingtao WangShuo Chen
Mar 24, 2021·Annales médico-psychologiques·Guillaume FondLaurent Boyer
Aug 12, 2021·Autism Research : Official Journal of the International Society for Autism Research·Giacomo VivantiLindsay L Shea
Dec 25, 2021·Neurocase·Takamitsu ShimadaYasuhiro Kawasaki
Jan 23, 2022·Schizophrenia Bulletin·Jolanta ZanelliJosephine Mollon

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