Schizophrenia genetics: dysbindin under the microscope

Trends in Neurosciences
Matthew A BensonDerek J Blake

Abstract

It is well established that genetic factors strongly contribute to the susceptibility of an individual to schizophrenia. Straub, Kendler and colleagues have published the first of several articles demonstrating a genetic association between schizophrenia and the gene encoding the dystrobrevin-binding protein dysbindin. Although no mutations in the dysbindin gene have been found, the recent identification of a specific risk haplotype in independent samples provides further evidence that dysbindin is a possible schizophrenia susceptibility gene.

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Citations

Jun 9, 2006·Molecular Biology of the Cell·G SalazarV Faundez
Apr 8, 2009·Human Molecular Genetics·Matthew LockeDerek J Blake
Dec 8, 2009·Science·Dion K Dickman, Graeme W Davis
Mar 21, 2013·Schizophrenia Bulletin·Katharina Domschke
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Feb 9, 2007·Journal of Cell Science·Karen Newell-LitwaVictor Faundez

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