Schizophrenia, ketamine and cannabis: evidence of overlapping memory deficits

Trends in Cognitive Sciences
Paul C Fletcher, Garry D Honey

Abstract

Drug models of mental illness are considered useful if they provoke its characteristic symptoms. In this respect, ketamine and tetrahydrocannabinol (cannabis) are coming under increasing scrutiny as models for schizophrenia. However, although both undoubtedly produce psychotic symptoms characteristic of the disorder, we argue here that, because schizophrenia is also accompanied by cognitive deficits, a full understanding of the impact of these drugs on cognition will be crucial in taking these models further. Memory deficits are pronounced in schizophrenia and we focus upon patterns of working and episodic memory impairment produced by ketamine and cannabis, identifying overlaps between drug and illness. We suggest that close attention to these deficits can offer insights into core pathophysiology of schizophrenia.

References

Aug 1, 1983·The Journal of Nervous and Mental Disease·L McClain
Mar 27, 1995·Psychiatry Research·K FlemingD R Weinberger
Sep 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·M B Bowers, J B Morton
Jul 1, 1993·The Journal of Nervous and Mental Disease·W W BeattyR D Staton
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·B L MurphyR H Roth
May 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A K MalhotraA Breier
Mar 1, 1997·Psychological Medicine·G BrébionJ M Gorman
Jun 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J D JentschR H Roth
Sep 1, 1997·Pharmacology, Biochemistry, and Behavior·S J HeishmanM L Stitzer
Mar 14, 1998·Psychopharmacology·J H KrystalD S Charney
Aug 13, 1998·Pharmacology, Biochemistry, and Behavior·R V FantW B Pickworth
Jan 14, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J W NewcomerJ W Olney
Aug 27, 1999·Psychopharmacology·J H KrystalD S Charney
Mar 23, 2000·Schizophrenia Research·A S ChanL Y Chow
May 4, 2001·Brain : a Journal of Neurology·P C Fletcher, R N Henson
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Jun 30, 2001·The American Journal of Psychiatry·W M PerlsteinJ D Cohen
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C L HartM W Fischman
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·E M KrupitskyJ H Krystal
Dec 26, 2001·Annual Review of Psychology·Endel Tulving
Nov 5, 2002·Schizophrenia Research·Daryl E Fujii, A Michael Wylie
Jan 7, 2003·Biological Psychiatry·Anthony P WeissStephan Heckers
Apr 2, 2003·The American Journal of Psychiatry·Joseph H CallicottDaniel R Weinberger
Jun 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer McDonaldHarriet de Wit
Jul 2, 2003·The American Journal of Psychiatry·Frank JessenReinhard Heun
Jul 31, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebekah A E HoneyP C Fletcher
Sep 5, 2003·Psychopharmacology·Philip D HarveyJohn H Krystal
Sep 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kyung-Heup AhnJun Soo Kwon
Oct 3, 2003·Nature Reviews. Neuroscience·Alan Baddeley
Nov 7, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Celia J A MorganH Valerie Curran
Feb 20, 2004·The International Journal of Neuropsychopharmacology·Anissa Abi-Dargham
Apr 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R A E HoneyP C Fletcher
May 1, 2004·Journal of Clinical Psychopharmacology·Anthony N NicholsonPhilip J Robson
Jun 1, 2004·The American Journal of Psychiatry·J Daniel RaglandRaquel E Gur
Jun 3, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Deepak Cyril D'SouzaJohn Harrison Krystal

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Citations

Sep 17, 2010·Psychiatry Research·Madeleine deVilleCarmel Loughland
May 24, 2011·Psychopharmacology·Jennifer T CoullPaul C Fletcher
Feb 10, 2016·Biological Psychiatry·Samantha J BroydNadia Solowij
Mar 26, 2013·CNS Neuroscience & Therapeutics·Susan MarlandPeter Paal
Jul 25, 2013·Human Psychopharmacology·Pierluigi SimonatoFabrizio Schifano
Mar 6, 2012·Human Psychopharmacology·Ornella CorazzaNorbert Scherbaum
Feb 21, 2013·CNS Neuroscience & Therapeutics·Ornella CorazzaFabrizio Schifano
Apr 25, 2013·CNS Neuroscience & Therapeutics·Bernat KocsisMihaly Hajos
Jul 23, 2011·Addiction·Celia J A MorganUNKNOWN Independent Scientific Committee on Drugs
Nov 3, 2010·Biological Psychiatry·Yanhui LiaoPaul C Fletcher
May 23, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Benjamin B Tournier, Nathalie Ginovart
Jul 19, 2015·Pharmacology, Biochemistry, and Behavior·Danielle ImpeyVerner J Knott
Apr 9, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francois GastambideGary Gilmour
Feb 18, 2011·Consciousness and Cognition·Leanne K WilkinsJ Allan Cheyne
Mar 1, 2015·Physiology & Behavior·Malcolm Hobbs, Wendy Kneller
Oct 25, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Juanita ToddStanley V Catts
Jun 26, 2014·The International Journal of Neuropsychopharmacology·Paulo R ShiromaKelvin O Lim
Jun 19, 2013·PloS One·Philip R CorlettPaul C Fletcher
Sep 29, 2006·Psychopharmacology·Celia J A Morgan, H Valerie Curran
Feb 6, 2015·Therapeutic Advances in Psychopharmacology·Hannah SteedsJames M Stone
Feb 7, 2007·Current Opinion in Psychiatry·Don Linszen, Therese van Amelsvoort
Oct 25, 2008·Psychopharmacology·Mark BlagroveBrigitte Brandner
Mar 11, 2010·Psychopharmacology·Robert A BattistiNadia Solowij
Aug 1, 2019·The American Journal of Drug and Alcohol Abuse·Alison C BurggrenEdythe D London
Nov 27, 2020·Psychopharmacology·Abril Rangel-PachecoTony W Wilson
Feb 3, 2021·Journal of Cannabis Research·Tim CurranL Cinnamon Bidwell
Jun 8, 2021·Journal of Psychopharmacology·John Martin CorkeryFabrizio Schifano

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