PMID: 6102186Mar 1, 1980

Schizophrenia-like psychosis caused by a metabolic disorder

Lancet
L PepplinkhuizenP Moleman

Abstract

Four patients with an intermittent psychosis closely resembling hallucinogenic drug-induced states were suspected of having a porphyric disease and were investigated for a possible relation between the metabolic dysfunctions of porphyria and the psychotic syndrome. Theoretically the link could be in a disturbance of serine and glycine metabolism. This theory was supported by disturbances in serine and glycine excretion found in all patients during psychotic episodes. In addition, loading with one low oral dose of serine produced psychotic symptoms 5 h later which lasted 3-6 h. One patient reacted to glycine in the same way. These findings suggest that disturbed serine-glycine metabolism may have a key role in certain schizophreniform psychotic syndromes.

References

Jan 1, 1978·The International Journal of Biochemistry·C H Gray
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Citations

Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·M J SchoutenJ H Wilson
May 1, 1986·Pharmacology, Biochemistry, and Behavior·M J Schouten, J Bruinvels
Jan 1, 1990·Pharmacology & Therapeutics·D J Nutt
Jun 1, 1984·Psychiatry Research·R WaziriJ Mott
Jun 1, 1985·Molecular and Cellular Endocrinology·J B Adams
Feb 1, 1982·Psychological Medicine·B Meldrum
Jul 9, 2004·Psychopathology·F M M A van der HeijdenW M A Verhoeven
May 1, 1983·Medical Hypotheses·F E Barr
Sep 10, 2014·SpringerPlus·Yukihiko ItoMakoto Satoh
Jul 1, 1983·Journal of Neurochemistry·R Rodnight
Feb 1, 2003·Acta Neuropsychiatrica·L PepplinkhuizenD Fekkes
Mar 15, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Abdulla A-B Badawy
Jul 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·R WaziriA D Sherman
Jul 1, 1983·Journal of Neurochemistry·J T Coyle
Jun 1, 1987·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·J Grabowski, V K Yeragani
Feb 24, 2005·Molecular and Cellular Biochemistry·Inmaculada López-FloresJuan Peragón
Jun 3, 2004·The Journal of Nutrition·Peter J Garlick

Related Concepts

Differential Diagnosis
Glycine, Sodium Hydrogen Carbonate
Disorders of Porphyrin Metabolism
Psychoses, Drug
Schizophreniform Disorders
Schizophrenia
Serine
Dermatologic Disorders
Antipsychotic Effect

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