PMID: 6102186Mar 1, 1980

Schizophrenia-like psychosis caused by a metabolic disorder

L PepplinkhuizenP Moleman


Four patients with an intermittent psychosis closely resembling hallucinogenic drug-induced states were suspected of having a porphyric disease and were investigated for a possible relation between the metabolic dysfunctions of porphyria and the psychotic syndrome. Theoretically the link could be in a disturbance of serine and glycine metabolism. This theory was supported by disturbances in serine and glycine excretion found in all patients during psychotic episodes. In addition, loading with one low oral dose of serine produced psychotic symptoms 5 h later which lasted 3-6 h. One patient reacted to glycine in the same way. These findings suggest that disturbed serine-glycine metabolism may have a key role in certain schizophreniform psychotic syndromes.


Jan 1, 1978·The International Journal of Biochemistry·C H Gray
Jan 1, 1976·Journal of the Chemical Society. Perkin Transactions 1·R BonnettA F McDonagh
Apr 1, 1952·The Journal of Mental Science·H OSMOND, J SMYTHIES


Aug 1, 1983·Pharmacology, Biochemistry, and Behavior·M J SchoutenJ H Wilson
May 1, 1986·Pharmacology, Biochemistry, and Behavior·M J Schouten, J Bruinvels
Jan 1, 1990·Pharmacology & Therapeutics·D J Nutt
Jun 1, 1984·Psychiatry Research·R WaziriJ Mott
Jun 1, 1985·Molecular and Cellular Endocrinology·J B Adams
Feb 1, 1982·Psychological Medicine·B Meldrum
Jul 9, 2004·Psychopathology·F M M A van der HeijdenW M A Verhoeven
May 1, 1983·Medical Hypotheses·F E Barr
Sep 10, 2014·SpringerPlus·Yukihiko ItoMakoto Satoh
Jul 1, 1983·Journal of Neurochemistry·R Rodnight
Feb 1, 2003·Acta Neuropsychiatrica·L PepplinkhuizenD Fekkes
Mar 15, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Abdulla A-B Badawy
Jul 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·R WaziriA D Sherman
Jul 1, 1983·Journal of Neurochemistry·J T Coyle
Jun 1, 1987·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·J Grabowski, V K Yeragani
Feb 24, 2005·Molecular and Cellular Biochemistry·Inmaculada López-FloresJuan Peragón
Jun 3, 2004·The Journal of Nutrition·Peter J Garlick

Related Concepts

Differential Diagnosis
Glycine, Sodium Hydrogen Carbonate
Disorders of Porphyrin Metabolism
Psychoses, Drug
Schizophreniform Disorders
Dermatologic Disorders
Antipsychotic Effect

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.