Schizophrenia patients' and psychiatrists' perspectives on ethical aspects of symptom re-emergence during psychopharmacological research participation

Psychopharmacology
Laura Weiss RobertsBrian B Roberts

Abstract

Study designs involving medication-free intervals have become the subject of controversy in the current dialogue on the ethics of serious mental-illness research. Schizophrenia patients ( n=59; response rate 75%; 48% inpatients) and psychiatrists ( n=70; response rate 83%) responded to ten questions about a hypothetical scenario in which a schizophrenia study participant experienced the re-emergence of serious symptoms during the "wash-out" phase of a psychopharmacological trial. Patients provided their personal views, and psychiatrists gave their personal views and made predictions as to how schizophrenia patients in general would respond. Schizophrenia patients and psychiatrists judged the hypothetical protocol as moderately harmful. Both expressed relatively low likelihood of willingness to participate in the study, given this potential outcome. Schizophrenia patients and psychiatrists found the decision fairly easy. Psychiatrists underestimated the level of harm and overestimated the difficulty of the decision as perceived by schizophrenia patients. Schizophrenia patients acknowledged that the offer of money and request by their doctor or family would increase the likelihood of their participation, and psychiatrists accurat...Continue Reading

Citations

Jan 4, 2012·European Archives of Psychiatry and Clinical Neuroscience·Hanfried Helmchen
Jul 21, 2004·Current Psychiatry Reports·Farzin IraniSteven J Siegel
Jan 1, 2011·AJOB Primary Research·James DuboisWhitney B Hadley
Nov 12, 2005·Schizophrenia Bulletin·Scott T Wilson, Barbara Stanley
Apr 28, 2006·Current Opinion in Psychiatry·Laura B Dunn, Laura Weiss Roberts
Apr 22, 2006·Ethics & Behavior·Raymond De VriesAndrew Goodgame
Feb 22, 2012·Perspectives in Clinical Research·Umesh Chandra Gupta, Saifuddin Kharawala
Nov 25, 2014·AJOB Empirical Bioethics·Cynthia GeppertKenneth Fletcher
Jun 10, 2010·International Review of Psychiatry·Emmanuel M NguiLaura Weiss Roberts
Sep 28, 2017·AJOB Empirical Bioethics·Laura Weiss Roberts, Jane Paik Kim
May 16, 2007·The Journal of Nervous and Mental Disease·Cherise RosenHenry W Dove

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