Schizophrenia patients with a history of childhood trauma have a pro-inflammatory phenotype

Psychological Medicine
U DennisonTimothy G Dinan

Abstract

Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ). Using enzyme-linked immunosorbent assay (ELISA) techniques, we measured peripheral levels of interleukin (IL)-1β, IL-6, IL-8 and tumour necrosis factor (TNF)-α. These immune parameters were compared in schizophrenia with childhood trauma, schizophrenia without childhood trauma and healthy controls. Patients with childhood trauma had higher levels of IL-6 and TNF-α than patients without trauma and healthy controls, and TNF-α levels correlated with the extent of the trauma. Patients with no trauma had similar immune profiles to controls. Childhood trauma drives changes, possibly epigenetic, that generate a pro-inflammatory phenotype.

References

Mar 1, 1992·Schizophrenia Research·D AddingtonJ Joyce
May 1, 1990·Physiology & Behavior·L G LeMayM J Kluger
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Aug 1, 1994·The American Journal of Psychiatry·D P BernsteinJ Ruggiero
Jul 10, 1993·British Dental Journal·S Hancocks
Aug 29, 2001·Development and Psychopathology·D Cicchett, E F Walke
Dec 3, 2003·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·T KvasnickaM Vrablik
Dec 17, 2003·Acta Psychiatrica Scandinavica·I JanssenJ van Os
Feb 26, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jochen Hardt, Michael Rutter
Mar 3, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Pekka TienariKarl-Erik Wahlberg
Jun 29, 2005·Schizophrenia Research·Stefan LeuchtRolf R Engel
Aug 2, 2005·Schizophrenia Research·Christine BraehlerSuzanne King
Sep 10, 2005·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·J Douglas Bremner
Jan 18, 2006·Journal of Affective Disorders·Sinead M O'BrienTimothy G Dinan
Sep 2, 2006·The American Journal of Psychiatry·Thaddeus W W PaceChristine M Heim
Sep 26, 2006·Journal of Autoimmunity·Rael D Strous, Yehuda Shoenfeld
Jan 5, 2007·The American Journal of Psychiatry·Mark ShevlinGary Adamson
Nov 17, 2007·Biological Psychiatry·Stéphane PotvinEdouard Kouassi
Dec 7, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L BrydonA Steptoe
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Apr 9, 2008·Archives of General Psychiatry·Andrea DaneseAvshalom Caspi
Jun 3, 2008·Schizophrenia Research·Rajiv TandonHenry A Nasrallah
Jul 8, 2008·Psychoneuroendocrinology·Christine HeimCharles B Nemeroff
Aug 30, 2008·European Journal of Endocrinology·Milos ZarkovićBozo Trbojević
Dec 3, 2008·Neuroimmunomodulation·Nathan L Sparkman, Rodney W Johnson
Feb 13, 2009·Human Psychopharmacology·Brian E Leonard, Ayemu Myint
Apr 21, 2009·Biological Psychiatry·Linda L CarpenterLawrence H Price
Nov 26, 2009·The Journal of Allergy and Clinical Immunology·Scott P ComminsJohn W Steinke
Oct 1, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Linda L CarpenterLawrence H Price
Oct 20, 2010·Progress in Neurobiology·Alan S Brown
Jan 25, 2011·Schizophrenia Research·Cherrie GalletlyAlexander McFarlane

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Citations

Nov 20, 2013·Neuroscience and Biobehavioral Reviews·Keith A FeigensonSteven M Silverstein
Jan 28, 2014·Psychopharmacology·Jessica J Stanis, Susan L Andersen
Sep 2, 2015·Psychoneuroendocrinology·Maria GariupAstrid Morer
Nov 12, 2013·Acta Psychiatrica Scandinavica·R CoelhoR Grassi-Oliveira
Sep 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Romina Mizrahi
Nov 18, 2014·Acta Psychiatrica Scandinavica·J BückerM Kauer-Sant'Anna
Sep 18, 2013·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Roksana Zakharyan, Anna Boyajyan
Aug 2, 2014·Developmental Cognitive Neuroscience·Prabarna Ganguly, Heather C Brenhouse
Jul 4, 2012·Brain, Behavior, and Immunity·Marco Di NicolaValeria Mondelli
Jun 21, 2014·Neuroscience and Biobehavioral Reviews·Błażej MisiakAndrzej Kiejna
Mar 19, 2014·Journal of Psychiatric Research·Mateus Luz LevandowskiRodrigo Grassi-Oliveira
Jan 21, 2015·Schizophrenia Research·Hui-Mei AnXiang Yang Zhang
Feb 12, 2015·Journal of Psychiatric Research·Tatiana FalconeAmit Anand
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Heather C Brenhouse, Jaclyn M Schwarz
Aug 27, 2016·Journal of Mental Health·John CrombyChris Talbot
Oct 26, 2016·Clinical Psychology Review·Lauren E GibsonLauren M Ellman
Sep 22, 2016·Schizophrenia Research·Suzi HongDilip V Jeste
Nov 23, 2017·Frontiers in Psychiatry·Milica Milovan BorovcaninMiodrag L Lukic
May 4, 2018·Biomedit︠s︡inskai︠a︡ khimii︠a︡·A E TaraskinaE M Krupitsky
Oct 9, 2015·Journal of Clinical Gastroenterology·Eamonn M M Quigley
Nov 30, 2019·Frontiers in Psychiatry·Shui JiangKatherine J Aitchison
Feb 7, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emma CarlssonMaria Faresjö
Mar 11, 2017·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jean-Philippe GouinWilliam B Malarkey
Jan 7, 2021·Molecular Neurobiology·Roberta Eduarda GrolliZuleide Maria Ignácio
Jan 12, 2021·Development and Psychopathology·Brie Reid, Andrea Danese
Nov 16, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M IoannouR A Schoevers
Oct 18, 2020·Molecular and Cellular Neurosciences·Jack Reddaway, Nichola M Brydges
Mar 20, 2021·Psychoneuroendocrinology·Błażej MisiakBrian J Miller
Nov 14, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shih-Jen Tsai

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