Schizophrenia patients with high intelligence: A clinically distinct sub-type of schizophrenia?

European Psychiatry : the Journal of the Association of European Psychiatrists
E ČernisJames H Maccabe

Abstract

Schizophrenia patients are typically found to have low IQ both pre- and post-onset, in comparison to the general population. However, a subgroup of patients displays above average IQ pre-onset. The nature of these patients' illness and its relationship to typical schizophrenia is not well understood. The current study sought to investigate the symptom profile of high-IQ schizophrenia patients. We identified 29 schizophrenia patients of exceptionally high pre-morbid intelligence (mean estimated pre-morbid intelligence quotient (IQ) of 120), of whom around half also showed minimal decline (less than 10 IQ points) from their estimated pre-morbid IQ. We compared their symptom scores (SAPS, SANS, OPCRIT, MADRS, GAF, SAI-E) with a comparison group of schizophrenia patients of typical IQ using multinomial logistic regression. The patients with very high pre-morbid IQ had significantly lower scores on negative and disorganised symptoms than typical patients (RRR=0.019; 95% CI=0.001, 0.675, P=0.030), and showed better global functioning and insight (RRR=1.082; 95% CI=1.020, 1.148; P=0.009). Those with a minimal post-onset IQ decline also showed higher levels of manic symptoms (RRR=8.213; 95% CI=1.042, 64.750, P=0.046). These findings pr...Continue Reading

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Citations

Apr 14, 2016·Schizophrenia Research·Theresa WimberleyChristiane Gasse
Apr 14, 2016·Neuroscience and Biobehavioral Reviews·Justin DavisMichael Berk
Apr 24, 2018·Journal of Neuropsychology·Margherita BechiRoberto Cavallaro
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Apr 5, 2020·NPJ Schizophrenia·Guangzao HuangJames J Cai
Mar 4, 2021·Expert Review of Neurotherapeutics·Mary V Seeman
May 18, 2021·Journal of Mental Health·Abigail C WrightKathryn Greenwood

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