Schizophrenia-spectrum patients treated with long-acting injectable risperidone in real-life clinical settings: functional recovery in remitted versus stable, non-remitted patients (the EVeREST prospective observational cohort study)

BMC Psychiatry
Elisabeth Giraud-BaroJoelle Obeid

Abstract

Previous studies showed functional improvement in stable patients with schizophrenia treated with risperidone long-acting injection (LAI). We therefore re-investigated functional improvement with risperidone LAI in remitted patients, in comparison with stable patients. The study was conducted in real-life conditions because of the high heterogeneity of the patients' situations. This was a multi-centre, prospective observational cohort study involving adult schizophrenia-spectrum chronic patients who were previously treated with risperidone LAI for 6 months. Remission was evaluated using the consensus criteria proposed by the Remission in Schizophrenia Working Group (RSWG). The primary endpoint was global functioning (assessed with the Global Assessment of Functioning scale, GAF) after one year of treatment. Social functioning was a secondary outcome. The analysis included 1490 patients. Attrition rate was 9.1 % at the end of the study. 27.7 % of patients were in remission after one year of risperidone LAI treatment. The mean GAF rating score (62.5 ± 1.5) was higher than the cut-off previously used to identify patients with satisfactory functioning (60) and significantly higher than the mean GAF score in stable, non-remitted pat...Continue Reading

References

Mar 3, 2005·The American Journal of Psychiatry·Nancy C AndreasenDaniel R Weinberger
Apr 7, 2005·International Clinical Psychopharmacology·Hans-Jürgen MöllerUNKNOWN StoRMi Study Group
May 24, 2005·Schizophrenia Research·Robert A LasserJohn M Kane
Sep 8, 2005·Journal of Psychopharmacology·W KisslingP M Llorca
Mar 30, 2007·Bipolar Disorders·A Martinez-AranJ L Ayuso-Mateos
Jan 22, 2009·Médecine sciences : M/S·Catherine Bonaïti-PelliéMahmoud Zureik
Feb 3, 2009·Neuropsychiatric Disease and Treatment·Michael K Rainer
Feb 13, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Paola RoccaFilippo Bogetto
May 28, 2010·The British Journal of Psychiatry. Supplement·W Wolfgang Fleischhacker
Nov 21, 2009·European Psychiatry : the Journal of the Association of European Psychiatrists·M LambertA Schreiner
Aug 10, 2010·Expert Opinion on Drug Safety·Fernando Cañas, Hans-Jürgen Möller
Sep 20, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·Y BrawY Levkovitz
Nov 16, 2012·Schizophrenia Research·Wing Chung ChangEric Yu Hai Chen
Sep 7, 2013·Psychiatry Research·Federica PinnaUNKNOWN Cagliari Recovery Study Group
Dec 8, 2014·Schizophrenia Research. Cognition·Federica PinnaBernardo Carpiniello

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Citations

Jul 5, 2017·Hormone Molecular Biology and Clinical Investigation·Salvatore Gentile
May 16, 2021·Brain and Behavior·Peter HuxleyRichard Warner
Nov 4, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·Ana CatalanPaolo Fusar-Poli

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