PMID: 8583968May 1, 1995Paper

Schizophrenia, suicide and the serotonin story

Medical Hypotheses
R J Holden

Abstract

In this paper, the relationship between schizophrenia, suicide and serotonin will be examined. Throughout, it will be argued that the fundamental problem does not lie with the neurotransmitter per se, but rather with uncontrolled fluctuations of brain glycaemic levels acting in conjunction with insulin resistance. It will be shown that the area of dopaminergic and serotonergic activity in the brain is intimately tied to the relative distribution of the central glucose transporters and, hence, to glucose metabolism and insulin activity. It will be argued that mania and positive schizophrenia represent a continuum of liability associated with hyperglycaemia, hyperdopaminergia, and hyperserotonergia. In contrast, depression and negative schizophrenia represent another continuum of liability involving hypoglycaemia, hypodopaminergia, and hyposerotonergia. This serves as a useful distinction in drawing together a large number of seemingly unrelated, diverse facts concerning both schizophrenia and suicide and, in particular, the possible relationship that obtains between cholesterol-lowering drugs, low serotonin and suicide. Essentially, this paper reaffirms a previously stated contention that mental illness, in its many guises, is a...Continue Reading

References

Oct 1, 1979·Psychiatry Research·G L BrownL F Major
Feb 1, 1979·Archives of General Psychiatry·J C BallengerG L Brown
Jan 1, 1979·Neuropsychobiology·M Virkkunen
Jan 1, 1992·Journal of Neurochemistry·G GuptaN Z Baquer
Mar 21, 1992·Lancet·H Engelberg
Dec 1, 1992·Schizophrenia Research·J B Lohr, K Flynn
Jun 1, 1992·International Clinical Psychopharmacology·P Nordström, M Asberg
Jan 1, 1992·The American Journal of Drug and Alcohol Abuse·D M Adams, J C Overholser
Jun 1, 1992·International Clinical Psychopharmacology·D G Grahame-Smith
Jan 1, 1992·The Medico-legal Journal·P H Sandifer
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·J M DavisW P Bartoli
Sep 1, 1992·The American Journal of Psychiatry·D C GoffE Amico
Jul 1, 1992·Schizophrenia Research·D W Black, R Fisher
Jun 15, 1992·Thrombosis Research·M H PietraszekT Yoshimi
Jan 1, 1992·European Archives of Psychiatry and Clinical Neuroscience·R Axelsson, M Lagerkvist-Briggs
Jan 1, 1992·International Clinical Psychopharmacology·B E Leonard
Mar 1, 1990·Journal of Neurochemistry·M P HeyesR N Auer
Jan 31, 1991·Biochemical and Biophysical Research Communications·H YanoH Imura
Nov 1, 1991·Psychosomatic Medicine·J R KaplanC Shively
Jul 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·T Tomov
Feb 1, 1991·The Journal of Toxicological Sciences·S Manabe, O Wada
Jan 1, 1991·The International Journal of Neuroscience·R Sandyk, S R Kay
Apr 1, 1991·The International Journal of Neuroscience·R Sandyk, S R Kay
Nov 15, 1990·The New England Journal of Medicine·A J ZametkinR M Cohen
Mar 1, 1985·Acta Psychiatrica Scandinavica·L LidbergL Bertilsson
Aug 1, 1989·Journal of Neurochemistry·S MéresseR Cecchelli
Feb 1, 1989·Acta Psychiatrica Scandinavica·P BråunigR Fimmers
Dec 1, 1987·Controlled Clinical Trials·J D NeatonJ A Cutler
Aug 1, 1986·Southern Medical Journal·R E LendingR N Hyland

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Citations

Apr 5, 2005·Brain Research·Maura BoldriniVictoria Arango
Aug 25, 1999·Biological Psychiatry·M D UnderwoodV Arango
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Laszlo G HarsingGyorgy Levay
Jun 1, 2006·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Julie O'SullivanWarren Ward
Mar 9, 2002·Clinical and Experimental Hypertension : CHE·Dhananjay N Umrani, Ramesh K Goyal
Dec 11, 2002·Clinics in Podiatric Medicine and Surgery·Susan M Walsh, Ronald A Sage
Feb 5, 2000·Equine Veterinary Journal. Supplement·K G CrandellS E Duren

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