PMID: 2114026Jan 1, 1990Paper

Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens

Psychopharmacology
N R SwerdlowM A Geyer

Abstract

Previous studies have demonstrated that several dopamine agonists disrupt sensorimotor gating as measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. Schizophrenic patients also exhibit deficits in PPI when the prepulse precedes the startle stimulus by less than 500 ms. In experiment 1, dopamine (0-40 micrograms) infused directly into the nucleus accumbens in rats caused a dose-dependent decrease in PPI at prepulse intervals shorter than 500 ms. In experiment 2, this effect of accumbens dopamine infusion on sensorimotor gating was found to vary with changes in prepulse intensity. These findings strongly suggest that increased mesolimbic dopamine activity is one substrate of the sensorimotor gating deficits in rats that are caused by treatment with dopamine agonists; similar substrates might mediate deficits in PPI exhibited by schizophrenic patients.

References

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Citations

Dec 13, 2006·Behavior Genetics·Sylvie TordjmanPierre L Roubertoux
Oct 24, 1994·Brain Research·R D BrintonW S Cheung
Apr 7, 1992·European Journal of Pharmacology·C W Callaway, M A Geyer
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·N R Swerdlow, M A Geyer
Sep 1, 1994·Pharmacology, Biochemistry, and Behavior·F J WanN R Swerdlow
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·N R SwerdlowM A Geyer
Nov 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·S B SchwarzkopfT Mitra
Jan 1, 1995·Brain Research Bulletin·D A Ott, R J Mandel
Jun 16, 2004·Behavioural Brain Research·Claudia F PlappertHans-Ulrich Schnitzler
Aug 26, 1998·Pharmacology, Biochemistry, and Behavior·S HartN R Swerdlow
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·Z A MartinezN R Swerdlow
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong

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