PMID: 9558Sep 1, 1976

Schizophrenic psychology, associative learning and the role of forebrain dopamine

Medical Hypotheses
R Miller


It is suggested that schizophrenic thinking can be explained as a lowering of levels of significance for acceptance of conclusions based on inductive logic. The formal similarity between inductive logic and operant, or classical conditioning is pointed out. It is thus possible to explain the therapeutic effects of neuroleptic drugs by referring to the effect of these, and related drugs, and of lesions of ascending dopamine pathways, on acquisition of conditioned responses. It is tentatively suggested that recognition of association of related features of the environment, whether in humans or animals occurs in the basal ganglia by a dopamine dependent process. A role is suggested for neocortical noradrenaline in consolidaton of newly acquired associations. Implications and tests of this hypothesis are discussed.


Jun 13, 1975·Science·L L Iversen
Feb 1, 1975·Journal of Clinical Pharmacology·R BerglingS Wold
Feb 7, 1975·Brain Research·L SteinC D Wise
Apr 25, 1975·Science·D G Amaral, J A Foss
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Oct 19, 1974·Lancet·E F Torrey, M R Peterson
Aug 1, 1973·Archives of General Psychiatry·J R Stevens
Apr 12, 1969·Lancet·D B CalneP Armitage
Nov 8, 1969·Lancet·D B CalneD R Laurence
Jun 27, 1970·Lancet·O W Sacks, M Kohl
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·S Ahlenius, J Engel
Jan 1, 1971·Naunyn-Schmiedebergs Archiv Für Pharmakologie·T H Svensson
Jan 1, 1969·Annual Review of Pharmacology·N E AndénJ Häggendal
Mar 1, 1970·The American Journal of Psychiatry·D J KupferF Snyder
Aug 1, 1972·Archives of General Psychiatry·S H Snyder
Jun 1, 1971·Journal of Neurology, Neurosurgery, and Psychiatry·G G MarshR Ansel
Mar 1, 1970·The Journal of Pharmacy and Pharmacology·S H Curry
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J W KebabianP Greengard
Oct 31, 1973·Nature: New Biology·D Tarsy, R J Baldessarini
Jan 1, 1973·Annual Review of Pharmacology·J L McGaugh
Jul 1, 1973·The Journal of Nervous and Mental Disease·M M Singh, J M Smith
Dec 1, 1973·The American Journal of Psychiatry·D S JanowskyH J Sekerke
May 1, 1973·Pharmacology, Biochemistry, and Behavior·M D Hamburg, R P Cohen
May 1, 1973·Pharmacology, Biochemistry, and Behavior·S Ahlenius
May 7, 1971·Nature·A A Boulton
Apr 1, 1967·Journal of Comparative and Physiological Psychology·I DivacM K Szwarcbart
Jan 1, 1967·Psychopharmacologia·A Randrup, I Munkvad
Jan 1, 1970·Brain : a Journal of Neurology·J M Kemp, T P Powell
Apr 21, 1969·Annals of the New York Academy of Sciences·I C Whitfield
Jun 1, 1965·Brain : a Journal of Neurology·N Geschwind
Sep 1, 1965·Brain : a Journal of Neurology·N Geschwind
Feb 16, 1967·The New England Journal of Medicine·G C CotziasL M Schiffer
Apr 1, 1970·European Journal of Pharmacology·B A BerkowitzS Spector
Jul 20, 1970·JAMA : the Journal of the American Medical Association·M J Meier, W E Martin
Oct 6, 1967·Psychopharmacologia·K Fuxe, C F Hanson
Mar 14, 1957·Annals of the New York Academy of Sciences·C C PFEIFFER, E H JENNEY
Apr 15, 1955·Annals of the New York Academy of Sciences·L E HOLLISTERR H ROBERTS
Jun 21, 1974·Science·S H SnyderD Greenberg


May 29, 2009·Psychopharmacology·Philip R CorlettPaul C Fletcher
Jul 14, 2010·Psychological Medicine·Graham K Murray
Dec 4, 2008·Nature Reviews. Neuroscience·Paul C Fletcher, Chris D Frith
Aug 9, 2007·Molecular Psychiatry·Graham K MurrayPaul C Fletcher
Aug 11, 2007·Brain : a Journal of Neurology·Philip R CorlettPaul C Fletcher
Jul 17, 2008·Schizophrenia Bulletin·Graham K MurrayPeter B Jones
May 11, 2010·Schizophrenia Bulletin·Andreas Heinz, Florian Schlagenhauf
May 10, 2008·BMC Psychiatry·Graham K MurrayLuise Poustka
Sep 12, 2015·The Lancet. Psychiatry·Philip R Corlett, Paul C Fletcher
Feb 16, 2016·Cognitive Neuropsychiatry·S K Fineberg, Philip R Corlett
Jun 19, 2010·Progress in Neurobiology·Philip R CorlettJ H Krystal
Dec 27, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seo Yeon Park, Ung Gu Kang
Sep 8, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ung Gu Kang
Feb 7, 2009·Biological Psychiatry·Florian SchlagenhaufAndreas Heinz
Jun 11, 2016·Schizophrenia Research. Cognition·Rafeef AbboudEileen M Joyce
Feb 9, 2017·Schizophrenia Bulletin·Erin J FeeneyPhilip R Corlett
Jun 27, 2007·Journal of Psychopharmacology·Philip R CorlettPaul C Fletcher
May 27, 2016·Journal of Psychopharmacology·Philip R CorlettPaul C Fletcher
Apr 4, 2002·The Australian and New Zealand Journal of Psychiatry·Jennifer Radden
Sep 19, 2008·Depression and Anxiety·Sara L WrightJon-Kar Zubieta
Jan 1, 1988·International Journal of Health Services : Planning, Administration, Evaluation·E Stark, A Flitcraft
Jan 1, 1991·International Journal of Aging & Human Development·M Bar-Yam
Sep 1, 1996·Medical Education·E M HundertJ Bickel
Jul 22, 2004·Journal of the American Academy of Nurse Practitioners·Susan Kleiman
Jan 1, 1997·Social Work in Health Care·M SormantiE Strainchamps
Jan 1, 1990·International Journal of Health Services : Planning, Administration, Evaluation·E Stark
Jan 1, 1995·International Journal of Health Services : Planning, Administration, Evaluation·E Stark, A Flitcraft
Dec 29, 2000·International Journal of Health Services : Planning, Administration, Evaluation·K G Gådin, A Hammarström
Jan 21, 2010·Journal of Mathematical Biology·Alan J Terry
Jan 7, 2010·Current Opinion in Psychiatry·Hisham Ziauddeen, Graham K Murray
Aug 3, 2005·The American Journal of Orthopsychiatry·Cassandra L Bransford
Apr 13, 2001·Journal of Personality and Social Psychology·J L Westmaas, R C Silver
Jan 1, 1990·Annals of the New York Academy of Sciences·M T Notman
Jun 18, 1996·Annals of the New York Academy of Sciences·J F Chisholm
Oct 24, 2000·Journal of Marital and Family Therapy·J Laird
Jan 8, 2020·Schizophrenia Bulletin·Anna L MoonKerrie L Thomas
Jan 11, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Robert A McCutcheonOliver D Howes
Apr 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Kelly M J Diederen, Paul C Fletcher
May 10, 2017·Frontiers in Neurology·Sara GarofaloGraham K Murray
Apr 5, 2017·Annual Review of Clinical Psychology·Juliet D Griffin, Paul C Fletcher
Jan 9, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Brandon GunasekeraSagnik Bhattacharyya

Related Concepts

Association Learning
Claustral Structure
Conditioned Reflex
Operant Conditioning
Memory Training
Schizophrenic Psychology

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