Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis.

Mitochondrion
Inge KühlNathalie Bonnefoy

Abstract

Complexes III and IV of the mitochondrial respiratory chain contain a few key subunits encoded by the mitochondrial genome. In Saccharomyces cerevisiae, fifteen mRNA-specific translational activators control mitochondrial translation, of which five are conserved in Schizosaccharomyces pombe. These include homologs of Cbp3, Cbp6 and Mss51 that participate in translation and the post-translational steps leading to the assembly of respiratory complexes III and IV. In this study we show that in contrast to budding yeast, Cbp3, Cbp6 and Mss51 from S. pombe are not required for the translation of mitochondrial mRNAs, but fulfill post-translational functions, thus probably accounting for their conservation.

References

May 1, 1992·The Plant Journal : for Cell and Molecular Biology·M MinetF Lacroute
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M C Costanzo, T D Fox
Nov 1, 1970·European Journal of Biochemistry·M L ClaisseP P Slonimski
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·D F SteeleT D Fox
Aug 1, 2002·The Journal of Biological Chemistry·Maria A Islas-OsunaCarol L Dieckmann
Oct 18, 2002·The Journal of Biological Chemistry·Yann Saint-GeorgesGeneviève Dujardin
Nov 1, 2003·The EMBO Journal·Xochitl Perez-MartinezThomas D Fox
Aug 13, 2004·The EMBO Journal·Antoni BarrientosAlexander Tzagoloff
Sep 21, 2007·The EMBO Journal·David U MickPeter Rehling
Dec 21, 2007·FEMS Yeast Research·Nick Fisher, Brigitte Meunier
Mar 5, 2008·Methods in Molecular Biology·Stéphane ChironNathalie Bonnefoy
May 10, 2008·IUBMB Life·Flavia FontanesiAntoni Barrientos
Dec 11, 2008·Methods in Molecular Biology·Karine GougetAntoni Barrientos
Aug 5, 2009·Nucleic Acids Research·Oliver RackhamAleksandra Filipovska
Oct 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Malgorzata Rak, Alexander Tzagoloff
Oct 28, 2009·Molecular and Cellular Biology·Flavia FontanesiAntoni Barrientos
Nov 21, 2009·Current Pharmaceutical Design·J M MatthewsJ P Mackay

❮ Previous
Next ❯

Citations

Oct 24, 2012·Antioxidants & Redox Signaling·Kirsten KehreinMartin Ott
Dec 10, 2015·Nitric Oxide : Biology and Chemistry·Rika Indri AstutiHiroshi Takagi
Apr 5, 2013·IUBMB Life·Flavia Fontanesi
Mar 28, 2012·Biochimica Et Biophysica Acta·Johannes M HerrmannNathalie Bonnefoy
Feb 25, 2018·The Journal of Biological Chemistry·Aldo E García-GuerreroXochitl Pérez-Martínez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.