Schlieren visualization of fluid dynamics effects in direct analysis in real time mass spectrometry

Rapid Communications in Mass Spectrometry : RCM
Matthew CurtisFacundo M Fernández

Abstract

The success of ambient analysis using plasma-based ion sources depends heavily on fluid dynamics and mass transport efficiency in the sample region. To help characterize the influence of these determining factors, visualization of the gas flow profile for a Direct Analysis in Real Time (DART) ion source at the mass spectrometer atmospheric pressure (AP) interface was performed using the Schlieren technique. The DART helium flow pattern was imaged in model systems incorporating different interface designs, i.e. skimmer or capillary inlet, and for sampling strategies using several types of traditional DART sample probes including a glass capillary, swab, and drug tablet. Notably, Schlieren experiments were conducted on instruments equipped with the gas-ion separator tube (GIST) adapter and Vapur® pump, and on setups featuring the transmission mode (TM) DART module used in standard practice. DART sources were seen to expel a collimated, highly laminar helium stream across interface distances up to ~8 cm. The helium stream was robust to the influence of gas temperature (50-500 °C) and flow rate (≤3.5 L min(-1) ), but considerable DART gas deflection or full disruption was observed in each sampling scenario. The severity of the flow...Continue Reading

References

Apr 15, 2005·Analytical Chemistry·Robert B CodyH Dupont Durst
Mar 19, 2008·Analytical Chemistry·Francisco J AndradeGary M Hieftje
Jun 25, 2009·Analytical Chemistry·Jason D HarperZheng Ouyang
Jul 31, 2009·Analytical and Bioanalytical Chemistry·Yueying LiuXinrong Zhang
Oct 13, 2009·Journal of the American Society for Mass Spectrometry·Manshui ZhouFacundo M Fernández
Feb 26, 2010·Journal of the American Society for Mass Spectrometry·Glenn A HarrisFacundo M Fernández
Jul 22, 2010·Journal of Mass Spectrometry : JMS·Lee Chuin ChenKenzo Hiraoka
Apr 15, 2011·Rapid Communications in Mass Spectrometry : RCM·Andrew H Grange, G Wayne Sovocool
Nov 3, 2011·Journal of the American Society for Mass Spectrometry·Glenn A HarrisFacundo M Fernández
Dec 15, 2012·Rapid Communications in Mass Spectrometry : RCM·Andrew H Grange
May 18, 2013·Rapid Communications in Mass Spectrometry : RCM·Christina M Jones, Facundo M Fernández
Mar 25, 2014·Journal of the American Society for Mass Spectrometry·Kevin P PfeufferGary M Hieftje

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Citations

Feb 18, 2016·Journal of the American Society for Mass Spectrometry·Joel D KeelorFacundo M Fernández
Jun 9, 2016·Mass Spectrometry Reviews·Matthew J PavlovichAdam B Hall
Oct 21, 2016·Journal of the American Society for Mass Spectrometry·Andrew P StoreyGary M Hieftje
May 10, 2019·Journal of the American Society for Mass Spectrometry·Walter WißdorfThorsten Benter
Jan 21, 2017·Analytical Chemistry·Patricia M PeacockSarah Trimpin

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