School-Aged Outcomes following Prenatal Methamphetamine Exposure: 7.5-Year Follow-Up from the Infant Development, Environment, and Lifestyle Study

The Journal of Pediatrics
Nwando EzeBarry Lester

Abstract

To assess the relationship between prenatal methamphetamine exposure (PME) and behavior problems at age 7.5 years and the extent to which early adversity mediated this relationship. The multicenter, longitudinal Infant Development, Environment, and Lifestyle study enrolled 412 mother-infant pairs at 4 sites. Methamphetamine-exposed participants (n = 204) were identified by self-report and/or gas chromatography/mass spectrometry confirmation of amphetamine and metabolites in infant meconium. Matched participants (n = 208) denied methamphetamine use and had a negative meconium screen. At the 7.5-year follow-up, 290 children with complete Child Behavior Checklist data and an early adversity index score were available for analysis (n = 146 exposed). PME was significantly associated with an increased early adversity index score (P < .001) and with increased externalizing, rule-breaking behavior, and aggressive behavior (P < .05). Early adversity was also associated with higher externalizing behavior scores. Early adversity significantly mediated the relationship between PME and behavioral problems. After adjusting the mediation model for sex, prenatal tobacco, alcohol, and marijuana exposures, and study site, the association of PME ...Continue Reading

References

Mar 1, 1985·Acta paediatrica Scandinavica·L BillingR Zetterström
Sep 1, 1996·Nursing Research·C T Beck
Jun 5, 2003·The American Journal of Psychiatry·Ralph E TarterDuncan Clark
Apr 2, 2005·Journal of Pediatric Psychology·Teresa J LinaresSonia Minnes
Dec 6, 2006·Archives of Pediatrics & Adolescent Medicine·Emalee G FlahertyHoward Dubowitz
Feb 3, 2007·Pediatrics·Henrietta S BadaRosemary Higgins
May 23, 2009·Obstetrics and Gynecology·Mishka TerplanHarold A Pollack
Apr 22, 2010·Journal of Addictive Diseases·Barry M Lester, Linda L Lagasse
Jul 6, 2010·Neurotoxicology and Teratology·Gale A RichardsonJennifer Willford
Oct 17, 2012·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Beau AbarBarry M Lester
Dec 3, 2014·Behavioural Brain Research·Annerine RoosKirsty A Donald
Feb 3, 2015·The Journal of Pediatrics·Brett J ManleyUNKNOWN Caffeine for Apnea of Prematurity CAP Trial Investigators

❮ Previous
Next ❯

Citations

Aug 6, 2020·Birth Defects Research·Joan D GareyAnthony R Scialli
Jun 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Lynne M Smith, Lucinda S Santos
Nov 7, 2019·European Journal of Pediatrics·Urs ZimmermannUNKNOWN Swiss neonatal abstinence syndrome study group
Dec 11, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Lisa E GravesJocelynn L Cook
Apr 6, 2021·Deutsches Ärzteblatt International·Lorenz HarstMario Rüdiger
Jun 19, 2021·Deutsches Ärzteblatt International·Lorenz HarstMario Rüdiger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.