Schwann Cell Responses and Plasticity in Different Dental Pulp Scenarios

Frontiers in Cellular Neuroscience
Eduardo Couve, Oliver Schmachtenberg

Abstract

Mammalian teeth have evolved as dentin units that enclose a complex system of sensory innervation to protect and preserve their structure and function. In human dental pulp (DP), mechanosensory and nociceptive fibers form a dense meshwork of nerve endings at the coronal dentin-pulp interface, which arise from myelinated and non-myelinated axons of the Raschkow plexus (RP). Schwann cells (SCs) play a crucial role in the support, maintenance and regeneration after injury of these fibers. We have recently characterized two SC phenotypes hierarchically organized within the coronal and radicular DP in human teeth. Myelinating and non-myelinating SCs (nmSCs) display a high degree of plasticity associated with nociceptive C-fiber sprouting and axonal degeneration in response to DP injuries from dentin caries or physiological root resorption (PRR). By comparative immunolabeling, confocal and electron microscopy, we have characterized short-term adaptive responses of SC phenotypes to nerve injuries, and long-term changes related to aging. An increase of SCs characterizes the early responses to caries progression in association with axonal sprouting in affected DP domains. Moreover, during PRR, the formation of bands of Büngner is observ...Continue Reading

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Citations

Dec 18, 2020·Frontiers in Cell and Developmental Biology·Hidefumi Maeda
May 28, 2021·Archives of Oral Biology·M WidbillerK M Galler
Jun 3, 2021·International Journal of Molecular Sciences·Yi YeJennifer Gibbs

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Methods Mentioned

BETA
Electron microscopy

Related Concepts