Schwann cells inhibit ectopic clustering of axonal sodium channels.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Matthew G VoasWilliam S Talbot

Abstract

The clustering of voltage-gated sodium channels at the axon initial segment (AIS) and nodes of Ranvier is essential for the initiation and propagation of action potentials in myelinated axons. Sodium channels localize to the AIS through an axon-intrinsic mechanism driven by ankyrin G, while clustering at the nodes requires cues from myelinating glia that interact with axonal neurofascin186 (Sherman et al., 2005; Dzhashiashvili et al., 2007; Yang et al., 2007). Here, we report that in zebrafish mutants lacking Schwann cells in peripheral nerves (erbb2, erbb3, and sox10/colorless), axons form numerous aberrant sodium channel clusters throughout their length. Morpholino knockdown of ankyrin G, but not neurofascin, reduces the number of sodium channel clusters in Schwann cell-deficient mutants, suggesting that these aberrant clusters form by an axon-intrinsic mechanism. We also find that gpr126 mutants, in which Schwann cells are arrested at the promyelinating stage (Monk et al., 2009), are deficient in the clustering of neurofascin at the nodes of Ranvier. When Schwann cell migration in gpr126 mutants is blocked, there is an increase in the number of neurofascin clusters in peripheral axons. Our results suggest that Schwann cells ...Continue Reading

References

Feb 1, 1973·Journal of the Neurological Sciences·W G Bradley, M Jenkison
Jun 14, 2002·Neuron·Darren T GilmourChristiane Nüsslein-Volhard
Dec 20, 2003·Nature Reviews. Neuroscience·Sebastian Poliak, Elior Peles
Mar 17, 2004·Current Opinion in Neurobiology·Alain Ghysen, Christine Dambly-Chaudière
Mar 31, 2005·Current Biology : CB·David A LyonsWilliam S Talbot
Sep 2, 2005·Nature Reviews. Neuroscience·Kristjan R Jessen, Rhona Mirsky
Feb 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lucy M Palmer, Greg J Stuart
Feb 17, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zayd M Khaliq, Indira M Raman
Aug 1, 2006·Developmental Biology·Hans-Martin PogodaWilliam S Talbot
Feb 7, 2007·The Journal of Cell Biology·Yang YangMatthew N Rasband
Mar 3, 2007·Current Biology : CB·Matthew G VoasWilliam S Talbot
Jun 6, 2007·The Journal of Cell Biology·Yulia DzhashiashviliJames L Salzer

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Citations

Aug 26, 1991·Biochimica Et Biophysica Acta·B JuulL Plesner
Jul 17, 1995·Biochimica Et Biophysica Acta·R P Oude ElferinkG M Groothuis
Dec 11, 1990·Biochimica Et Biophysica Acta·P ThomasG Steele
Oct 4, 2011·Development·Julie R PerlinWilliam S Talbot
Aug 7, 2012·Disease Models & Mechanisms·Kelly R MonkWilliam S Talbot
Oct 31, 2015·Cellular and Molecular Life Sciences : CMLS·Sean A FreemanNathalie Sol-Foulon
Feb 7, 2012·The International Journal of Biochemistry & Cell Biology·Martin KriebelHansjürgen Volkmer
Oct 12, 2010·Seminars in Cell & Developmental Biology·Christophe LeterrierHelene Vacher
Jun 12, 2010·Current Opinion in Neurobiology·Matthew S Grubb, Juan Burrone
Mar 20, 2016·Cellular and Molecular Neurobiology·Rodrigo Lopez-Leal, Felipe A Court
Sep 8, 2010·Neuroscience Letters·Christophe LeterrierBénédicte Dargent
May 24, 2015·Annual Review of Genomics and Human Genetics·Jasmine M McCammon, Hazel Sive
Oct 19, 2016·Cytoskeleton·Rodrigo López-LealFelipe A Court
Dec 3, 2016·PLoS Genetics·Laura FontenasMarcel Tawk
Dec 21, 2019·Developmental Neurobiology·Yael Eshed-Eisenbach, Elior Peles
Oct 26, 2018·Frontiers in Cellular Neuroscience·Laura Fontenas, Sarah Kucenas
May 18, 2018·Frontiers in Neurology·Nádia Pereira GonçalvesLone Tjener Pallesen
Nov 7, 2020·International Journal of Molecular Sciences·Grazia MaugeriVelia D'Agata
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Lynn NazarethJenny Ekberg

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