Schwannoma of the gastrointestinal tract: a clinicopathological, immunohistochemical and ultrastructural study of 33 cases

Histopathology
Y Y HouX Z Zhu

Abstract

Thirty-three cases of gastrointestinal schwannomas were analysed to elucidate their peculiar clinicopathological, immunohistochemical and ultrastructural features. The patients were 16 men and 17 women, whose ages ranged from 27 to 81 years (median 52.6 years). Tumour size ranged from 10 to 120 mm in diameter. Follow-up in 23 cases from 6 months to 13 years showed no recurrences or metastases. Microscopically, all tumours were composed of spindle cells with focal epithelioid cells in four cases. In all cases except one, there were peripheral cuff-like lymphoid aggregates. Immunohistochemically, tumours were strongly positive for S100 protein and vimentin, the tumours were variably positive for nestin (78.8%, 26/33) and glial fibrillary acidic protein (63.6%, 21/33), three tumours had CD34+ cells, but all were negative for CD117, alpha-smooth muscle actin and desmin. Ultrastructurally, the tumours were composed of elongated spindle shaped cells with prominent parallel membranous structures. Gastrointestinal schwannomas have characteristic histological features, especially the presence of a lymphoid cuff, that are different from their soft tissue and central nervous system counterparts. Gastrointestinal tract schwannomas behave i...Continue Reading

References

Feb 1, 1995·The American Journal of Surgical Pathology·M Miettinen Maarit-Sarlomo-Rikala
Oct 1, 1993·The American Journal of Surgical Pathology·S W Weiss, B J Nickoloff
Aug 1, 1996·The Surgical Clinics of North America·L D BrittK Maull
Oct 1, 1995·Histopathology·M Sarlomo-Rikala, M Miettinen
Mar 1, 1997·Human Pathology·N YagihashiS Yagihashi
Mar 9, 2000·World Journal of Surgery·G F HatchJ E Skandalakis
Jun 23, 2001·The American Journal of Surgical Pathology·M MiettinenL H Sobin
Jun 30, 2001·Human Pathology·J Berman, T J O'Leary
Nov 2, 2001·The American Journal of Surgical Pathology·G R MeiningerJ M Hare
Feb 19, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eva WardelmannTorsten Pietsch
Jul 3, 2002·Human Pathology·Christopher D M FletcherSharon W Weiss
Aug 24, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Maarit Sarlomo-RikalaMarkku Miettinen
Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Mar 18, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Angela D LevyMarkku Miettinen
Dec 6, 2003·Oncology·Florence Duffaud, Jean-Yves Blay
Apr 17, 2004·The American Journal of Surgical Pathology·Hidetaka YamamotoMasazumi Tsuneyoshi
Jan 19, 2005·The American Journal of Gastroenterology·Thomas TranHashem B El-Serag
Feb 25, 2005·AJR. American Journal of Roentgenology·Angela D LevyLeslie H Sobin

❮ Previous
Next ❯

Citations

Jul 25, 2007·Abdominal Imaging·Min Kyu JungHan Ik Bae
Jan 5, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Daisuke KomatsuShinichi Miyagawa
Dec 13, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Brian K P GohWai-Keong Wong
Mar 18, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ying-Yong HouAndrea Frilling
Aug 28, 2007·The American Journal of Surgical Pathology·Alessandra F Nascimento, Christopher D M Fletcher
Jun 4, 2008·The American Journal of Surgical Pathology·Bernadette LieglChristopher D M Fletcher
Aug 18, 2010·Pathology International·Yetish SingShamim Bux
Jun 15, 2011·BMC Gastroenterology·Elena Guerini RoccoSolange Romagnoli
Aug 2, 2013·Diagnostic Pathology·Dongxian JiangXiongzeng Zhu
Jan 23, 2013·Diagnostic Pathology·Yuan ShiYunshan Tan
May 14, 2009·World Journal of Gastroenterology : WJG·Paola PasquiniFranca Del Nonno
Jan 18, 2013·World Journal of Gastroenterology : WJG·Dan-Dan ZhongJian-Ting Cai
Feb 2, 2013·Archives of Pathology & Laboratory Medicine·Anshu Trivedi, Saverio Ligato
Aug 27, 2013·International Surgery·Vishal G ShelatAaryan Koura
May 17, 2012·World Journal of Surgical Oncology·Hun Jin KimHyeong Rok Kim
Apr 25, 2007·Advances in Anatomic Pathology·Susan C Abraham
Jun 27, 2007·Advances in Anatomic Pathology·Richard KirschRobert Riddell
May 29, 2012·Gastrointestinal Endoscopy Clinics of North America·Amer A Alkhatib, Douglas O Faigel
Sep 19, 2009·Gastroentérologie Clinique Et Biologique·G GauchotteK Montagne
Jan 24, 2014·Brain Pathology·David A Hilton, Clemens Oliver Hanemann
May 13, 2015·The Surgical Clinics of North America·Cindy HaJohn D Mellinger
Nov 9, 2011·Journal of the Korean Surgical Society·Ki Jae ParkHong Jo Choi
Jan 22, 2015·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hyung-Chul ParkYoung-Eun Joo
Jul 2, 2010·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jongmee LeeKee-Taek Jang
Sep 23, 2016·AJR. American Journal of Roentgenology·Kanae K MiyakeKaori Togashi
Oct 21, 2016·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Rafael Dienstmann Dutra VilaAdriano Calcagnotto Garcia
Mar 16, 2016·Clinical Endoscopy·Jong Min YoonGeun Am Song
Sep 24, 2018·BMJ Case Reports·JayaKrishna Chintanaboina, Kofi Clarke
Apr 26, 2013·Neurologia Medico-chirurgica·Tatsuya KobayashiYoshimasa Mori
Sep 30, 2020·Surgical Case Reports·Shuichi FukudaMasatoshi Inoue

❮ Previous
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