Sci-Sat AM: Brachy - 09: Permanent seed re-implantation using image guidance for composite dose planning

Medical Physics
Tyler MeyerW Smith

Abstract

Treatment outcome has been associated with dosimetric implant quality assessed in a postplan. Uncertainties during the implant and in the period before postplan evaluation lead to dosimetric deviations from the original treatment plan. The observed range of postplan results can include patients with dosimetry below recommended levels. Further treatment options may be considered to boost the delivered dose and a second seed implant is one way to accomplish this. This work describes the development of a procedure to plan and deliver a second seed implant and an evaluation of the dosimetric improvement. A patient with a post-plan D90 of 124 Gy was offered a second seed implant 21 weeks after the initial implant. A total dose of 163 Gy was prescribed due to radiobiological considerations for the time between implants. A volume study was performed 2 weeks before the implant and variable angle images of the seeds from the first implant were obtained to reconstruct the original seed coordinates. The second implant was planned considering the total composite physical dose distribution by forward planning additional seeds onto the original implant coordinates. The additional seeds were manually added to a new plan on the volume study im...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.