Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration

Plastic and Reconstructive Surgery
F KanayaW C Breidenbach

Abstract

The purpose of this study was to determine which parameters were the best measure of nerve regeneration, assuming that the sciatic functional index (SFI) represented the "gold standard." Three different sciatic functional indexes and 11 commonly used electrophysiologic and morphologic indicators of regeneration were all determined in 24 rats 12 weeks after one of three lesions was created in the sciatic nerve. With linear regression analysis, only fiber/axon diameter ratio (D/d) and myelin thickness/axon diameter ratio showed statistically significant correlations with sciatic functional index (r = 0.55 and 0.53, respectively). The other 11 parameters had poorer correlation. Therefore, if sciatic functional index is the best measure of comprehensive nerve function, then other parameters are not. It is probable that each parameter measures some different component of the regeneration process. A stepwise multiple linear regression analysis produced a model that included D/d, nerve conduction velocity, and nerve action potential amplitude that gave a slightly better correlation (r = 0.67). The relatively poor correlation between sciatic functional index and the other parameters of nerve function indicates that all nerve regenerati...Continue Reading

References

Jul 1, 1976·The Journal of Hand Surgery·J K TerzisR W Hakstian
Oct 1, 1991·Plastic and Reconstructive Surgery·E S Dellon, A L Dellon
Jan 1, 1990·Journal of Reconstructive Microsurgery·M J BuehlerJ R Urbaniak
Sep 1, 1989·Annals of Plastic Surgery·A L Dellon, S E Mackinnon
Jan 1, 1989·Plastic and Reconstructive Surgery·J R BainD A Hunter

❮ Previous
Next ❯

Citations

Jul 9, 1998·Muscle & Nerve·C A MunroR Midha
Aug 29, 2012·Tissue Engineering. Part B, Reviews·Mark SzynkarukGregory H Borschel
Oct 8, 1999·Plastic and Reconstructive Surgery·L L PuJ G Thomson
Feb 21, 2003·Journal of Neurosurgery·Güzin Yeşim Ozgenel, Gülaydan Filiz
May 18, 2006·Journal of Neurosurgery·Serçin TirelioğluBezhat Noyan
Mar 2, 2006·Journal of Neurosurgery. Spine·Serhat Ozbek, M Ayberk Kurt
Apr 10, 2004·Neurological Research·Stefano GeunaMaria G Giacobini-Robecchi
Apr 10, 2004·Neurological Research·Artur S VarejãoJosé Bulas-Cruz
Jun 3, 2014·BMC Musculoskeletal Disorders·Lihong FanKunzheng Wang
May 30, 2009·Biomedical Microdevices·Valeria ChionoGianluca Ciardelli
Dec 18, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Rahim MohammadiKeyvan Amini
Oct 9, 2002·Journal of the Peripheral Nervous System : JPNS·Tomas HaapaniemiLars B Dahlin
Dec 17, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Kongkrit ChaiyasateVijay Mittal
Dec 20, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Rahim MohammadiSeyedeh-Sepideh Sajjadi
Oct 18, 2008·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Han HaishengLi Xin
Jul 28, 2009·Journal of the American College of Surgeons·Jason M SeeryJose M Pizarro
Aug 30, 2008·Journal of Neuroscience Methods·B S Stefan de KoolGerhard H Visser
Mar 19, 2008·Journal of the Peripheral Nervous System : JPNS·Huan WangAnthony J Windebank
Aug 4, 2006·Journal of Biomedical Materials Research. Part a·Ming-Hong ChenFeng-Huei Lin
Sep 18, 2007·Journal of the Peripheral Nervous System : JPNS·Godard C de RuiterAnthony J Windebank
Oct 24, 2008·Microsurgery·Ioannis PapakostasConstantinos Pantos
Sep 14, 2013·Journal of the Peripheral Nervous System : JPNS·Stephen W P KempGregory H Borschel
Apr 10, 2010·The European Journal of Neuroscience·Stephen W P KempRajiv Midha
May 4, 2012·Journal of Tissue Engineering and Regenerative Medicine·Bai-Shuan LiuChiung-Chyi Shen
Dec 23, 2015·Neural Regeneration Research·Rafet ÖzayYusuf Şükrü Çağlar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.