PMID: 9175014Apr 1, 1997Paper

SCID-bg mice as xenograft recipients

Laboratory Animals
S ShibataK Doi

Abstract

SCID-bg (scid/scid, beige/beige) is a strain of double-mutant mice with impaired lymphoid development and reduced natural killer (NK) cell activity. The present study was undertaken to evaluate the usefulness of SCID-bg mice as xenograft recipients. Fetal guinea pig tissues (liver, thymus, spleen) were transplanted under the kidney capsule of the mice and their serum guinea pig IgG levels were measured weekly thereafter, C.B.-17-scid and anti-asialo GM1 antiserum-treated (NK-depleted) C.B.-17-scid (C.B.-17-scid-AGM1) mice that received the identical transplants were used as controls. Throughout the experimental period (1, 2, and 3 weeks after transplantation), the average serum guinea pig IgG concentrations was highest in C.B.-17-scid-AGM1 mice followed by SCID-bg mice and lowest in C.B.-17-scid mice without antiserum treatment, though we could not find any statistical significance among these groups. However, SCID-bg mice always showed the smallest within-group variance (individual difference) in the serum guinea pig IgG concentrations (P < 0.05, versus C.B.-17-scid-AGM1 mice at 1, 2, and 3 weeks and versus C.B.-17-scid mice at 2 weeks). The graft size was not significantly different among these three groups, but the spleen gr...Continue Reading

Citations

Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·Madiha KhalidMuhammad Ashraf
Jun 30, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Heather J BelmontHing C Wong
Mar 19, 2015·Biochimica Et Biophysica Acta·K A LodhiaC L Scott
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·A S BoehleM Neumaier
Dec 22, 1999·Clinical and Experimental Immunology·K G TournoyG G Leroux-Roels
Nov 17, 2017·The Journal of Toxicological Sciences·Kenichiro KasaharaMariko Nagatani
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilia N BuhtoiarovAlexander L Rakhmilevich
Aug 8, 2020·Journal of Cellular and Molecular Medicine·Shanshan ZhaoGuihua Hou
Nov 10, 1998·European Journal of Immunology·K G TournoyR A Pauwels

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