Science to Practice: Killing Dormant Cells-Is Targeting Autophagy the Key to Complete Tumor Response in Transarterial Chemoembolization?

Radiology
Lynn Jeanette SavicJean-Francois H Geschwind

Abstract

In this issue of Radiology, Gade et al ( 1 ) describe a unique mechanism of hepatocellular carcinoma (HCC) cells for surviving ischemia induced by transarterial embolization (TAE)/transarterial chemoembolization (TACE) in a state of cell cycle arrest-a function that may serve as a defensive shield against conventional chemotherapeutic agents. This finding adds to our knowledge and establishes a previously poorly understood mechanism of chemoresistance in HCC. As the Achilles heel in terms of this process, a concurrent upregulation of autophagic flux as an adaptive response to TAE-like ischemia was found by the authors. This is a targetable mechanism that can potentially be exploited for combined therapeutic approaches of embolotherapy and autophagy inhibition in HCC.

References

Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Apr 19, 2012·Cell Cycle·James R ValcourtHilary A Coller
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Quentin McAfeeRavi K Amaravadi
Apr 10, 2013·International Journal of Biological Sciences·Lu GaoLi-xin Wei
Apr 13, 2015·Journal of Vascular and Interventional Radiology : JVIR·Terence P F GadeM Celeste Simon
Mar 18, 2016·Journal of Clinical Medicine Research·Kang LiuXiao-Ming Zhang
Mar 3, 2017·Radiology·Terence P F GadeM Celeste Simon

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