Science to practice: the dawn of molecular US imaging for clinical cancer imaging

Radiology
Fabian Kiessling

Abstract

Ultrasonography (US) is one of the most commonly used diagnostic modalities in clinical medicine. Gas-filled microbubbles can be used to enhance the contrast of tumors by indicating increased vascularity. Because microbubbles can be detected with high sensitivity and specificity, they fulfill an important precondition for use as a molecular imaging probe. Over the past several years, there have been an increasing number of published studies that showed that markers of angiogenesis and inflammation can be assessed reliably when microbubbles are coupled to antibodies and peptides. Recently, target-specific microbubbles have been developed that are suited for use in humans. Now the identification of the optimal clinical indications for molecular US imaging in clinics is required. In this context, advantages and limitations of US with targeted microbubbles, when compared with other imaging modalities, must be carefully considered. Because US is a transportable, cheap, real-time imaging modality, molecular US imaging may have advantages for initial tumor screening and US-guided interventions; furthermore, it may support therapy monitoring in intervals between whole-body images obtained with positron emission tomography (PET), comput...Continue Reading

References

Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Grzegorz KorpantyRolf A Brekken
Feb 10, 2009·Current Medicinal Chemistry·F KiesslingM Palmowski

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Citations

Mar 21, 2013·Investigative Radiology·Jean-Marc HyvelinFrançois Tranquart
Jun 20, 2014·Nature Reviews. Cancer·Marion de JongWytske M van Weerden
Nov 23, 2011·Cancer Letters·Sukhwinder KaurSurinder K Batra
Apr 28, 2011·Gastrointestinal Endoscopy·Marcos C PedrosaUNKNOWN ASGE Technology Committee
Jan 25, 2011·Gastroenterology·Marybeth A Pysz, Jürgen K Willmann
Oct 26, 2011·Contrast Media & Molecular Imaging·Ronald X Xu
Apr 22, 2015·Current Problems in Diagnostic Radiology·Roberto García-FigueirasDow-Mu Koh
Jul 2, 2017·Journal of Endocrinological Investigation·M Del PreteUNKNOWN ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
Nov 2, 2020·Gastrointestinal Endoscopy·Kumar KrishnanUNKNOWN (ASGE Technology Committee Chair)

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