Scientific basis for use of Pyrus pashia Buch.-Ham. ex D. Don. fruit in gastrointestinal, respiratory and cardiovascular ailments

PloS One
K H JanbazMarius Moga

Abstract

Pyrus pashia Buch.-Ham. ex D. Don. has been used conventionally by many communities in the Himalayan region for the management of gastrointestinal, respiratory, and vascular complications. Set against this background, this study was carried out to justify the scientific basis to validate folkloric uses of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr) in traditional systems of medicine. The crude ethanol extract of fruits of Pyrus pashia Buch.-Ham. ex D. Don. (Pp.Cr) was tested in vitro on isolated rabbit jejunum, tracheal, and aorta preparations. The responses of tissues were recorded using isotonic transducers coupled with a PowerLab data acquisition system. The Pp.Cr on application (0.01-5.0 mg/ml) to isolated rabbit jejunum preparation exhibited relaxation through decrease in magnitude and frequency of spontaneous contractions. The Pp.Cr also exerted a relaxant (0.01-5.0 mg/ml) effect on K+ (80 mM) induced contractions in isolated rabbit jejunum preparations and caused shifting of the Ca2+ curves (1.0-3.0 mg/ml) toward right in a manner similar to that of verapamil (3 μM), possibly suggesting presence of Ca2+ channel blocking activity. Subsequently, Pp.Cr in a concentration-dependent fashion (0.01-10.0 mg/ml) caused r...Continue Reading

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Citations

Sep 12, 2015·BMC Complementary and Alternative Medicine·Fatima SaqibMuhammad Zia-Ul-Haq
Dec 30, 2017·Nutritional Neuroscience·Priyanka SharmaSiva Hemalatha
Jan 5, 2019·International Journal of Geriatric Psychiatry·Quratul Ain, Haroon Khan
Dec 23, 2017·Asian Pacific Journal of Tropical Medicine·Hafiz Muhammad Abdur RahmanImran Imran
Aug 18, 2018·Frontiers in Pharmacology·Muhammad Faraz KhanCassandra L Quave
Oct 27, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Hafiz Muhammad Abdur RahmanImran Imran
Sep 3, 2021·BMC Complementary Medicine and Therapies·Sung-Yong HongMihi Yang

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