Scientific Impact Recognition Award: Molecular breast imaging: a review of the Mayo Clinic experience.

American Journal of Surgery
Carrie B HruskaMichael K O'Connor

Abstract

Molecular breast imaging (MBI) depicts functional uptake of targeted radiotracers in the breast using dedicated gamma cameras. MBI studies were performed under several institutional protocols evaluating the use of MBI in screening and diagnosis. By using a single-head system, sensitivity for breast cancer detection was 85% (57 of 67) overall and 29% for tumors 5 mm or less in diameter. Sensitivity improved to 91% (117 of 128) overall and 69% for tumors 5 mm or less using a dual-head system. In 650 high-risk patients undergoing breast cancer screening, MBI detected 7 cancers, 5 of which were missed on mammography. In 24 of 149 (16%) breast cancer patients MBI detected additional disease not seen on mammography. The sensitivity of MBI was 88% (83 of 94) for invasive ductal carcinoma, 79% (23 of 29) for invasive lobular carcinoma, and 89% (25 of 28) for ductal carcinoma in situ. MBI can detect invasive ductal carcinoma, ductal carcinoma in situ, and invasive lobular carcinoma. It has a promising role in evaluating the extent of disease and multifocal disease in the breast for surgical treatment planning.

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Citations

Sep 1, 2011·Cancer Biotherapy & Radiopharmaceuticals·Fan-Lin KongDavid J Yang
Mar 24, 2010·Radiology·Mark B WilliamsStanislaw Majewski
Jul 24, 2014·AJR. American Journal of Roentgenology·Jessica M HoBradley Handler
Mar 8, 2013·The Surgical Clinics of North America·Dana H Smetherman
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Aug 13, 2009·Expert Review of Anticancer Therapy·Michael O'ConnorCarrie Hruska
Jan 1, 2012·American Society of Clinical Oncology Educational Book·Thierry AndréJeffrey A Meyerhardt
Mar 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nikunj B BhattThaddeus J Wadas
Jan 27, 2020·Seminars in Cancer Biology·Nicoletta UrbanoOrazio Schillaci
Sep 8, 2016·Journal of Nuclear Medicine Technology·John F Valliant
Feb 3, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Wendie A Berg

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