Scintigraphic and tomographic evaluation of biological activities of prefabricated free and vascularized bone allografts

The Journal of Craniofacial Surgery
Gokhan KocaUgur Kocer

Abstract

We performed an experimental study on rabbits to compare the biologic activities of free and vascularized cortical and corticocancellous solvent-dehydrated bone allografts by scintigraphy and three-dimensional computed tomography (CT). Twenty New Zealand white rabbits (2500-3000 g) were divided into 2 groups each consisting 10 animals. In group 1, solvent-dehydrated human cadaveric cranium allografts (corticocancellous bone) were used. The grafts were divided into 20 pieces, approximately 10 × 10 × 5 mm. On the right ears, grafts were placed on dissected vascular bundles. On their left ears, allografts were implanted into subcutaneous pockets without dissecting any vascular bundle. The same procedure was performed in group 2 with solvent-dehydrated human cadaveric fibula bone allografts (cortical bone). No infection or any animal death occurred during 12 months of observation. At the end of the 12th month, implanted bone allografts were evaluated by 3-phase bone scintigraphy to observe the circulation and viability of the grafts and three-dimensional CT scans to measure their dimensions. Radioactive uptake by scintigraphy of grafts placed on vascular bundle was higher than grafts placed in pockets. t-Test was calculated for reg...Continue Reading

References

Jun 1, 1991·Annals of Plastic Surgery·H B EvansL N Hurst
Oct 1, 1986·Journal of Reconstructive Microsurgery·G A SolomonP N Manson
Nov 1, 1988·Annals of Plastic Surgery·S JenkinsW J Barwick
May 1, 1988·British Journal of Plastic Surgery·T TakatoT Nakatsuka
Nov 12, 1965·Science·M R Urist
Sep 3, 1999·The Orthopedic Clinics of North America·S Stevenson
Sep 3, 1999·The Orthopedic Clinics of North America·W W Tomford, H J Mankin
Jan 29, 2003·European Journal of Nuclear Medicine and Molecular Imaging·Reingard M AignerErich Sorantin
Apr 20, 2004·Journal of Reconstructive Microsurgery·Kwang Suk LeeJong Ryoon Baek

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Citations

Oct 26, 2016·EBioMedicine·Ru-Lin HuangQingfeng Li
Nov 14, 2013·The Journal of Craniofacial Surgery·Hasan Ikbal AtilganDuygu Kankaya

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