Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead

Journal of Occupational Health
Teresa Wrońska-NoferWojciech Wąsowicz

Abstract

Occupational exposure to lead may produce kidney damage, but existing data on the dose range associated with nephrotoxicity are inconclusive. We here assessed renal function under conditions of low to moderate lead exposure using renal scintigraphy. Fifty-three male foundrymen (exposed group) and fourty male office workers (control group) from a steel plant were included in the study. Glomerular and tubular renal function were assessed by means of (99m)Tc-DTPA and (99m)Tc-EC clearance, respectively. Urinary markers of glomerular dysfunction (albumin) and tubular damage (α1-microglobulin (α1M), β2-microglobulin (β2M), retinol-binding protein (RBP), N-acetyl-β-glucosaminidase (NAG) activity) were determined using latex beads tests or colorimetry. The lead concentration in blood was measured with atomic absorption spectrometry. The blood lead concentrations were 145.8 (121.3-175.3) and 39.3 (35.1-44.1) µg/l (geometric mean, 95(th) CI, p<0.001) in the exposed and control groups, respectively. Subjects exposed to lead presented with increased (99m)Tc-DTPA clearance (158.3 (148.4-168.8) vs. 135.9 (127.9-144.4) ml/min; p<0.01) and urinary albumin excretion (7.61 (6.28-9.22) vs. 4.78 (4.05-5.65) mg/g creatinine; p<0.001). (99m)Tc-EC cl...Continue Reading

References

May 1, 1992·Kidney International·F Khalil-ManeshV J Rosen
Jan 15, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·A BlumsohnC F Ramsey
May 1, 1993·Bulletin of Environmental Contamination and Toxicology·G EndoS Horiguchi
Jan 1, 1994·International Archives of Occupational and Environmental Health·M Kentner, T Fischer
Aug 1, 1994·Occupational and Environmental Medicine·H RoelsD Chettle
Jan 1, 1993·British Journal of Industrial Medicine·A CárdenasI Franchini
Jan 1, 1997·International Archives of Occupational and Environmental Health·J S LaiP Y Chang
Sep 25, 1997·Environmental Health Perspectives·M Loghman-Adham
Nov 17, 1998·Occupational and Environmental Medicine·R EhrlichP Landrigan
Aug 6, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L J PetersenH A Jensen
May 1, 2002·International Archives of Occupational and Environmental Health·Francis PierreJean-François Fabriès
Oct 10, 2002·International Archives of Occupational and Environmental Health·Ven-Shing WangJim-Shoung Lai
Jul 29, 2003·Occupational and Environmental Medicine·V M WeaverB S Schwartz
May 19, 2004·Environmental Research·M Trzcinka-OchockaA Gazewski
Jan 1, 2005·Environmental Health Perspectives·Virginia M WeaverByung-Kook Lee
Oct 21, 2005·Journal of the American Society of Nephrology : JASN·Christine WhiteGreg A Knoll
Jun 22, 2006·Kidney International·P PalatiniUNKNOWN HARVEST Study Group
Oct 26, 2006·Kidney International·E B EkongV M Weaver
May 5, 2009·Toxicology and Applied Pharmacology·Tadeusz HalatekWojciech Wasowicz
May 5, 2010·Advances in Chronic Kidney Disease·Peter SoderlandJames S Kaufman
Oct 15, 2010·Kidney International·Marie Evans, Carl-Gustaf Elinder
Oct 27, 2010·Occupational and Environmental Medicine·Virginia M WeaverByung-Kook Lee
May 12, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Banu AygunRussell E Ware
Sep 10, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Imed HelalRobert W Schrier
Jul 10, 2012·Diabetes Care·Piero RuggenentiUNKNOWN GFR Study Investigators
Jan 1, 2001·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals· A Karakaya Z Karaaslan Y Duydu B Yücesoy G Oflaz S K Köse

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Citations

Aug 9, 2016·Annals of Epidemiology·Sangshin Park, Nam-Kyong Choi
Jan 27, 2019·Environmental Science and Pollution Research International·Mohamed Anouar NouiouiAbderrazek Hedhili
Aug 21, 2018·Environment International·Marzie BoskabadyMohammad Hossein Boskabady

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