PMID: 8583349Oct 1, 1995Paper

Scintigraphic assessment of the oropharyngeal and nasal depositions of fusafungine from a pressurized inhaler and from a novel pump spray device

The Journal of Pharmacy and Pharmacology
S P NewmanJ Brickwell

Abstract

The distributions of fusafungine (Locabiotal, Servier) radiolabelled with 99mTc, and delivered either orally or intranasally, have been assessed in healthy volunteers from a pressurized metered-dose aerosol inhaler (125 micrograms per dose) and from a novel mechanical pump spray device (500 micrograms per dose). More than 90% of the dose was initially deposited in the oropharynx for oral dosing (n = 8), and more than 90% in the nose for nasal dosing (n = 9), with no significant penetration of aerosol into the lungs. Although not statistically significant, the mean area of deposition, measured in terms of gamma camera picture elements (pixels), was greater with the pump spray for both oral and nasal dosing. The area of deposition with the nasal pump spray extended into the turbinates in six of nine subjects, compared with only three of nine subjects for the pressurized aerosol. The data suggest that the distribution patterns of pump sprays and pressurized aerosols of fusafungine in the oropharynx and in the nasal passages are similar, and that the former can be substituted for the latter with little change in drug delivery.

References

Jan 1, 1977·Mayo Clinic Proceedings·M Hasegawa, E B Kern
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Oct 1, 1988·The Pediatric Infectious Disease Journal·J Siegel
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Citations

Jul 4, 2012·Pharmaceutical Research·William H DoubLucinda F Buhse
Jun 6, 2000·Advanced Drug Delivery Reviews·M T Vidgren, H Kublik
Oct 30, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Z LeeD L Heald
Sep 2, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Xiao Bing ChenDe Yun Wang
Sep 11, 2001·American Journal of Therapeutics·V V Ranade
Dec 18, 2007·Journal of Pharmaceutical Sciences·Robert J Garmise, Anthony J Hickey
Jan 16, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S CharltonL Illum
Jun 26, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E KivisaariM J Price

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