Scintigraphic characteristics of experimental myocardial infarct extension

Circulation
M W KronenbergA B Brill

Abstract

Technetium-99m-stannous pyrophosphate scintiphotos were evaluated for diagnosing and quantitating myocardial infarct (MI) extension in sedated dogs. Infarction and extension were produced by serial left anterior descending coronary artery ligations at 0 and 48 hours. We compared serial scintiphoto data with regional myocardial blood flow (MBF) (microsphere technique) and infarct histopathology. In eight control dogs, the scintigraphic MI area was stable at 24, 48, and 72 hours. In each of 11 dogs undergoing extension, the MI area increased after the 48-hour occlusion, averaging a 48.9% increase (p less than 0.001). Grossly, most extensions were mixtures of confluent necrosis and moderate (patchy) necrosis. MBF to confluent infarct tissue decreased significantly, allowing the documentation of extension by totaling the grams of newly flow-deprived tissue, but patchy infarct tissue had little flow deprivation, making it difficult to quantitate this type of extension accurately by flow criteria alone. Rarely, extension could be diagnosed using conventional histologic criteria. We concluded that the scintiphoto MI area was related quantitatively to infarct weight in both control and extension. However, it was not possible to determi...Continue Reading

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Citations

Sep 1, 1987·Progress in Cardiovascular Diseases·H F Weisman, B Healy
May 1, 1985·Journal of the American College of Cardiology·R A Slutsky, W W Peck
Feb 1, 1985·Journal of the American College of Cardiology·R A Slutsky, M Murray
May 11, 2002·The Journal of the Acoustical Society of America·Thomas L Geers, Kendall S Hunter
Apr 1, 1982·The American Journal of Cardiology·B L Holman

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