Scintigraphic measurements of canine ileocolonic transit. Direct and indirect effects of eating

Gastroenterology
R C SpillerF Azpiroz

Abstract

Eight dogs were equipped with ileal catheters, 50 cm proximal to the ileocolonic junction, and serosal electrodes at 5, 25, 55, 100, and 150 cm. Transit was assessed by injecting a bolus of 99mTc-diethylenetriamine pentaacetic acid through the ileal catheter and following isotope movements by serial, 4-min scintiscans. Isotope was injected in separate studies: during phase I of an interdigestive myoelectrical cycle, 10 min before a meal, and or 2 or 4 h after a meal (600 ml, 385 kcal, thickened with 4 g guar). At another time, mouth-to-colon transit of the same meal was measured by labeling it with 111In-diethylenetriamine pentaacetic acid and scanning at hourly intervals for 11 h. Transit of isotope through the terminal ileum and entry into the colon was characteristically erratic; long periods of immobility were interspersed with sudden "bolus" movements. In the fasting studies, most sudden movements occurred while phase III (migrating motor complex) of the interdigestive myoelectrical cycle migrated through the last 50 cm of ileum. Passage of a single migrating motor complex through the terminal ileum propelled about one-half the dose of isotope into the colon; complete clearance of the ileum required two or more migrating m...Continue Reading

Citations

Feb 10, 1999·The American Journal of Physiology·P G DinningI J Cook
Jun 3, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P G DinningI J Cook
Dec 2, 2009·Digestive Diseases and Sciences·Annemie DeiterenAlan R Zinsmeister
Feb 2, 2019·Alimentary Pharmacology & Therapeutics·Victoria Wilkinson-SmithRobin Spiller
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H P LefebvreP L Toutain
Aug 1, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G MajorR Spiller
Nov 24, 1999·The American Journal of Physiology·P G DinningI J Cook
Oct 31, 2021·Alimentary Pharmacology & Therapeutics·Neele DellschaftRobin Spiller

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