PMID: 22331718Feb 15, 2012Paper

Scintimammography and single-photon emission computed tomography for postoperative image guidance for radiation treatment planning in breast cancer patients

Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
E PiperkovaM Dimitrova

Abstract

To evaluate post-surgical tumor-metabolic regions outside of the computed tomography (CT)-defined volume for radiation therapy (RT) planning using functional imaging of scintimammography (SMG) ± single photon emission computerized tomography (SPECT) in breast cancer (BC) patients. 62 operated high-risk BC females, mean age 50.45 years, underwent SMG±SPECT before RT planning. Twenty-one and twelve patients with stage I and IIa respectively had lumpectomy (LT) with axillary lymph node dissection (ALND), and modified radical mastectomy (Patay) + ALND was realized in 29 stage IIb-III patients. All SMG images, positive for viable tumor tissue (VTT) or metastatically involved lymph nodes (LNs) were verified cytologically/ histologically. Three early planar and delayed images were acquired after i.v. administration of 550-740 MBq 99mTc- MIBI or 99mTc-TF. Uptake values (UV) > 1.65 revealed VTT. Data in 49 (79%) of 62 patients were characterized as true-negative (TN; UV<1.35). In 13 (21%) patients SMG visualized 22 true-positive (TP) malignant lesions: 2 residual VTT in scars, 1 newly defined BC in the contralateral breast and 18 regional LN metastases (6 axillary, 6 parasternal, 1 sub- and 5 supraclavicular). All 22 TP VTT lesions were...Continue Reading

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