PMID: 8940710Aug 1, 1996Paper

Scintimammography with Tc-99m MIBI in patients with suspicion of primary breast cancer

Nuclear Medicine and Biology
H PalmedoH J Biersack

Abstract

The aim of the study was to evaluate the diagnostic accuracy of scintimammography with Tc-99m MIBI for the detection of breast cancer. Patients with a suspicious lesion detected by palpation or mammography were included in the study. Excisional biopsy was performed on all patients. Mammography was performed within 3 weeks prior to scintigraphy. All patients received 740 MBq Tc-99m MIBI intravenously in the arm contralateral to the suspicious breast and were subsequently examined in a prone position. At 5 to 10 min postinjection, planar images were obtained in lateral and anterior views, with an acquisition time of 10 min each. After planar imaging, a SPECT study was performed using a two-head camera. Breast cancer was confirmed in 29 out of 68 patients. The tumor size ranged from 6 to 90 mm in diameter. For scintigraphic studies, the overall sensitivity and specificity was 83% and 84%, respectively. However, sensitivity for palpable lesions was 100%. The smallest detectable tumor measured 9 mm in diameter and could be visualized only in the planar scintigram. Using Tc-99m MIBI, axillary lymph node metastases could be detected with a sensitivity of 82%. Scintigraphy with Tc-99m MIBI has a high diagnostic accuracy for the detecti...Continue Reading

References

Mar 1, 1992·AJR. American Journal of Roentgenology·D B Kopans
Aug 1, 1992·Annals of Nuclear Medicine·H J BiersackW J Shih
Aug 1, 1983·Archives of Surgery·P I Pressman

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Citations

Nov 28, 2002·Nuclear Medicine and Biology·Holger PalmedoHans Jürgen Biersack
Nov 6, 1998·Nuclear Medicine and Biology·E BarbaricsA G Jones
Jul 5, 2002·Clinical Radiology·D GopalanP J Ell
Sep 28, 2002·Medical Physics·Frederic H FaheyRichard L Webber

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