Scleroderma Renal Crisis Complicated with Thrombotic Microangiopathy Triggered by Influenza B Virus Infection

Internal Medicine
Toshimasa ShimizuAtsushi Kawakami

Abstract

A 44-year-old Japanese man with a 14-year history of limited cutaneous systemic sclerosis (SSc) was admitted with a fever, hypertension, anemia, thrombocytopenia, and renal dysfunction. On admission, hypertension, hyperreninemia, acute renal dysfunction, hemolytic anemia, and thrombocytopenia led to the diagnosis of scleroderma renal crisis (SRC) complicated with thrombotic microangiopathy (TMA). The patient had also been infected with influenza B virus almost six days before admission. Following treatment with plasma exchange, an angiotensin-converting enzyme inhibitor, and an anti-virus agent, his general condition improved. He had no risk factors for SRC. In SSc patients, an influenza virus infection might trigger SRC complicated with TMA.

References

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Citations

Jun 13, 2020·Journal of Nephrology·Claudio PonticelliGabriella Moroni
Oct 27, 2020·KI Reports·Lilian Monteiro P PalmaSanjeev Sethi
Apr 17, 2021·Infection and Drug Resistance·Liang ChenXiqian Xing
Jun 11, 2020·Kidney & Blood Pressure Research·Magdalena ChrabaszczLidia Rudnicka

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Methods Mentioned

BETA
biopsy

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