Scleroderma renal crisis in a newly diagnosed mixed connective tissue disease resulting in dialysis-dependent chronic kidney disease despite angiotensin-converting enzyme inhibition

CEN Case Reports
Muhammad Abdul Mabood KhalilJackson Tan

Abstract

Mixed connective tissue disease (MCTD) is a rheumatic disease with a combination of multiple connective tissue disorders, which includes dermatomyositis or polymyositis, systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and Sjögren's syndrome. It affects various organs of the body, which includes the lungs, heart, kidneys, joints, muscles and the haematological system. Here, we report a case of MCTD consisting of scleroderma, Sjögren's syndrome and polymyositis complicated by scleroderma renal crisis (SRC) but with negative anti-nuclear antibody (ANA), anti-Scl 70 and anti-centromere antibodies. The patient was started on captopril for the treatment of SRC but developed chronic kidney disease despite adequate blood pressure control with angiotensin-converting enzyme inhibitor (ACEi).

References

Nov 1, 1986·Seminars in Arthritis and Rheumatism·R C KitridouS G Massry
Jun 1, 1987·Australian and New Zealand Journal of Medicine·R M CrapperJ A Whitworth
May 1, 1984·The American Journal of Medicine·V D SteenG P Rodnan
Aug 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K SatohY Nakamoto
Nov 18, 1997·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·Y Farhey, E V Hess
Oct 18, 2000·Annals of Internal Medicine·V D Steen, T A Medsger
Aug 9, 2005·Rheumatic Diseases Clinics of North America·Janet E Pope
Nov 23, 2006·Clinical Rheumatology·Mehmet CelikbilekNurhan F Ozdemir
Jul 3, 2007·QJM : Monthly Journal of the Association of Physicians·H PennC P Denton
Nov 1, 2008·Human Pathology·Ibrahim BatalSheldon Bastacky
Jun 12, 2009·Rheumatology·C P DentonU Müller-Ladner
Sep 10, 2010·International Journal of Rheumatology·Victoria K Shanmugam, Virginia D Steen
Oct 29, 2010·International Journal of Rheumatology·Ibrahim BatalSheldon Bastacky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.