Sclerosing angiomatoid nodular transformation (SANT): report of 25 cases of a distinctive benign splenic lesion

The American Journal of Surgical Pathology
Maritza MartelJuan Rosai

Abstract

Twenty-five cases of a morphologically distinctive vascular lesion of the spleen are described. The patients were 17 women and 8 men, ranging in age from 22 to 74 years (mean, 48.4 years; median, 56 years). The most common presentations were incidental finding of an asymptomatic splenic mass (13 patients), abdominal pain or discomfort (6 patients), and splenomegaly (4 patients). None of the patients had evidence of recurrent disease after splenectomy. The splenic lesion was solitary, measuring 3 to 17 cm, and sharply demarcated from the surrounding parenchyma. The cut surface revealed a mass of coalescing red-brown nodules embedded in a dense fibrous stroma. All cases showed a remarkably consistent multinodular appearance at low-power examination. The individual nodules had an angiomatoid appearance, in the sense that they were composed of slit-like, round or irregular-shaped vascular spaces lined by plump endothelial cells and interspersed by a population of spindly or ovoid cells. Some of the nodules (particularly the smaller ones) were surrounded by concentric rings of collagen fibers. Numerous red blood cells were present, as well as scattered inflammatory cells. Nuclear atypia was minimal, mitotic figures were extremely ra...Continue Reading

References

Aug 1, 1978·American Journal of Clinical Pathology·M L Silverman, V A LiVolsi
Aug 1, 1990·Cancer·P H WiernikS F Morris
Jun 1, 1989·Histopathology·S Falk, H J Stutte
Sep 1, 1986·Journal of Surgical Oncology·H D AlpernA J Kozak
Jan 1, 1970·Acta Neuropathologica·S Nurick, W G Mair
Jun 1, 1983·Pathology, Research and Practice·F J Pardo-MindanE Rocha
Jul 1, 1997·The American Journal of Surgical Pathology·D A ArberL M Weiss
Aug 30, 2003·Seminars in Diagnostic Pathology·Jayashree Krishnan, Glauco Frizzera
Aug 30, 2003·Seminars in Diagnostic Pathology·Jeffery L Kutok, Christopher D M Fletcher

❮ Previous
Next ❯

Citations

Jan 25, 2008·Der Pathologe·M HartmannT Rüdiger
Sep 21, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A ChiuA Orazi
Jul 25, 2006·The American Journal of Surgical Pathology·Susan FernandezDaniel A Arber
Apr 22, 2009·AJR. American Journal of Roentgenology·Lindsay M ZeebDavid P Keating
Mar 26, 2013·AJR. American Journal of Roentgenology·Rachel B LewisNadine S Aguilera
Aug 3, 2010·World Journal of Gastroenterology : WJG·Jia-Ying CaoWen-Ping Wang
Sep 3, 2013·Archives of Pathology & Laboratory Medicine·Dinesh Pradhan, Sambit K Mohanty
Dec 17, 2011·World Journal of Surgical Oncology·Zong-Qiang HuLi Li
Feb 4, 2011·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Z MohrS Willis
Sep 20, 2015·Abdominal Imaging·Michyla BowersonKhaled Elsayes
Aug 12, 2015·Journal of Ultrasound·Guido MenozziElena Tagliavini
Jun 25, 2015·Singapore Medical Journal·Hock Tai Gavin LimChi Shern Bernard Ho
Aug 4, 2012·International Journal of Surgery Case Reports·Gavin A FalkSteven Rosenblatt
Jun 9, 2009·Medicina clínica·Meritxell Lluís PadiernaLluís Colomo
Dec 17, 2009·Annales de pathologie·Kristina OpletalováJacques Chasle
May 12, 2007·Virchows Archiv : an International Journal of Pathology·Ilan WeinrebBayardo Perez-Ordoñez
Dec 25, 2016·International Journal of Surgery Case Reports·Yasuo NagaiShigehiro Shiozaki
Aug 12, 2009·International Journal of Surgical Pathology·Aashiyana F KoreishiJulie Teruya-Feldstein
May 28, 2010·International Journal of Surgical Pathology·Fabio Facchetti
Dec 22, 2011·Yonsei Medical Journal·Mukul DivatiaJae Y Ro
Nov 9, 2011·Journal of the Korean Surgical Society·Ki-Han KimGhap Joong Jung
Jan 10, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jun-Ke WangFu-Yu Li
Sep 13, 2015·The Kaohsiung Journal of Medical Sciences·Yen-Cheng ChenKung-Kai Kuo
Oct 4, 2008·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Devrim A KaraosmanogluDeniz Akata
Mar 31, 2010·Journal of Computer Assisted Tomography·Ty K SubhawongIhab Kamel
Aug 25, 2010·Advances in Anatomic Pathology·Wah Cheuk, John K C Chan
Apr 10, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Basma M Basha, Eric D Hsi
Nov 7, 2019·Journal of Computer Assisted Tomography·Jianbing MaXiaofeng Yang
Aug 26, 2014·Ultrasound Quarterly·Megan LeeHisham Tchelepi
Mar 26, 2014·Clinical Nuclear Medicine·Constantin LapaKen Herrmann
Aug 16, 2016·The American Journal of Surgical Pathology·Kung-Chao ChangL Jeffrey Medeiros

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.