Sclerosing mediastinitis of unknown origin: Report of a case

International Journal of Surgery Case Reports
Soichi OkaFumihiro Tanaka

Abstract

We herein describe a rare case of a sclerosing mediastinitis without IgG4-related disease. This case was clearly excluded from IgG4-related disease, because this patient's serum IgG4 level was not elevated. Specifically, this patient's serum IgG4 level was 7.9mg/dl (4.8-105). A 61-year-old Japanese female presented at our hospital due to an abnormal chest X-ray that showed a growing shadow in the mediastinum. Chest computed tomography (CT) showed an 80×75×75mm tumor, which located in the anterior mediastinum. This large tumor surrounded the thoracic aorta, left brachiocephalic vein and superior vena cava. It was difficult to obtain a definitive diagnosis. We tried to perform three biopsies, and eventually performed a partial resection of the tumor. This case did not fit the criteria for IgG4-related disease, and it was therefore unclear whether steroid therapy should be used for this case. We will continue to carefully follow up this patient's residual lesion, and there have been no changes in the lesion at present. Sclerosing mediastinitis and IgG4-related disease should be included in the differential diagnosis of patients presenting with a mediastinal tumor. However, sclerosing mediastinitis is difficult to diagnose, and it ...Continue Reading

References

May 16, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·J A Cooper
Jul 9, 2008·World Journal of Gastroenterology : WJG·Terumi Kamisawa, Atsutake Okamoto
Oct 4, 2011·Current Rheumatology Reports·Arezou KhosroshahiJohn H Stone

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Citations

Aug 25, 2016·Clinical Reviews in Allergy & Immunology·Giovanni M RossiAugusto Vaglio

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Methods Mentioned

BETA
X-ray
biopsy

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