Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported

Human Pathology
Gabriela Quiroga-GarzaJae Y Ro

Abstract

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid is a rare traditionally "low-grade" tumor that predominantly occurs in women. Approximately 50 cases have been reported in the literature. It arises in a background of Hashimoto thyroiditis and is characterized by nests of epidermoid and mucin-secreting cells located within an eosinophil-rich sclerotic stroma. Herein, we outline the clinicopathological and immunohistochemical characteristics of 6 cases of thyroid SMECE. All tumors were detected in women (age, 36-89 years; average, 59 years), and all patients underwent total thyroidectomies. Clinicopathological findings included extensive tumor invasion into the adjacent soft tissues, trachea, pharynx, and esophagus. Of 6 specimens, 5 had positive surgical margins. Cervical lymph node metastases were seen in 4, and distant metastases were in 3 patients. Immunohistochemically, all tumors were positive for CK19, galectin 3, and p63 and negative for calcitonin, calponin, S-100, and smooth muscle actin. Interestingly, 2 tumors also showed faint focal staining for thyroglobulin, and 2 others had focal positivity for thyroid transcription factor 1. Together, galectin 3 and CK19 expression supported the malign...Continue Reading

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Dec 3, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akeesha A ShahRaja R Seethala
Dec 15, 2017·Histopathology·Zubair W Baloch, Virginia A LiVolsi
Nov 14, 2019·JCO Oncology Practice·Bryce D BeutlerTejvir Singh
May 11, 2018·Endocrine Pathology·Zubair BalochSylvia L Asa
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Jul 8, 2020·Endocrine Pathology·José Manuel Cameselle-TeijeiroManuel Sobrinho-Simões
Aug 11, 2021·Surgical Pathology Clinics·Juan C Hernandez-Prera

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