Sclerosing mucoepidermoid carcinoma with eosinophilia: Cytologic characterization of a rare distinct entity in the thyroid

Diagnostic Cytopathology
Erik AmesEric C Huang

Abstract

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is an extremely rare thyroid carcinoma with limited cytologic descriptions in the literature. Here, we present a 52-year-old woman with a 3.9 cm thyroid nodule. Fine-needle aspiration smears consisted of a highly cellular specimen with tumor cells in isolated patterns and solid squamoid nests. Tumor cells had round to oval nuclei, prominent nucleoli, smooth nuclear contours, and moderate amounts of dense cytoplasm. In addition to the polymorphous population of lymphocytes, the background contained a striking abundance of eosinophils. The subsequent right thyroidectomy showed histologic features diagnostic for SMECE.

References

Mar 12, 1998·American Journal of Clinical Pathology·K R GeisingerD H Buss
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Z W BalochV A LiVolsi
Mar 11, 2004·American Journal of Otolaryngology·Nasfat J ShehadehJohn F Ensley
Apr 18, 2008·Indian Journal of Pathology & Microbiology·S Das, R Kalyani
Oct 6, 2012·Cancer Science·Haruna NodaHiroshi Inagaki
Mar 25, 2016·Journal of Cytology·Chayanika PantolaSudeep Thakur
Dec 3, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Akeesha A ShahRaja R Seethala
May 31, 2017·Histopathology·Elizabeth Y WuJustine A Barletta
Aug 20, 2017·American Journal of Clinical Pathology·Nada A FarhatWilliam C Faquin

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Citations

Jun 21, 2020·Head and Neck Pathology·Meagan ChambersDarcy A Kerr
Jul 17, 2020·Cytopathology : Official Journal of the British Society for Clinical Cytology·Jong-Hee NamYoo-Duk Choi
Aug 11, 2019·BMJ Case Reports·Haissan IftikharSaira Fatima

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