Sclerosing papillary lesion of the breast: a diagnostic pitfall for malignancy in fine needle aspiration biopsy

Diagnostic Cytopathology
Reda S SaadAnisa Kanbour

Abstract

Papillary neoplasms of breast constitute a group of lesions that show broad spectrum of morphological changes, ranging from benign to malignant and posing challenges at all diagnostic levels. Some benign papillary lesions may form well-defined solid masses with a dominant sclerosed architecture, known as complex sclerosing papillary lesion or simply sclerosing papilloma. The purpose of this study is to apply the previously published criteria for papillary lesions and to identify the cytomorphologic findings that lead to false-positive diagnosis of these cases. We reviewed the fine needle aspiration biopsies (FNAB) of six histologically proven sclerosing papilloma that were called suspicious or malignant on FNAB. The patient age ranged from 40 to 69, with a mean of (43 +/- 6) yr. Three patients presented with a palpable lump and two patients had history of fibrocystic disease. All six patients had abnormal screening mammograms. FNAB was performed using a 23-gauge syringe attached to a commercial holder. FNA smears were markedly hypercellular with large number of epithelial fragments and papillary clusters, discohesive single cells that are hyperchromatic with mild to moderate nuclear pleomorphism. Bipolar cells were present in a...Continue Reading

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Citations

Oct 22, 2008·Clinical Radiology·M J Brookes, A G Bourke
Nov 11, 2018·ANZ Journal of Surgery·Yue YuPhilip J Crowe
Feb 28, 2009·World Journal of Gastroenterology : WJG·Seung-Goun HongYoung-Tae Bak
May 2, 2007·Advances in Anatomic Pathology·Anna Marie Mulligan, Frances P O'Malley
Nov 15, 2017·Cytopathology : Official Journal of the British Society for Clinical Cytology·J WeignerP McElduff
Jun 6, 2009·Archives of Pathology & Laboratory Medicine·Shir-Hwa UengFattaneh A Tavassoli

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