Sclerosing skin disorders in association with multiple sclerosis. Coincidence, underlying autoimmune pathology or interferon induced?

Annals of the Rheumatic Diseases
T HügleU A Walker

Abstract

To describe and analyse the manifestation of sclerosing skin disorders in patients with multiple sclerosis (MS). We describe three patients with relapsing-remitting MS who developed skin sclerosis while receiving interferon (IFN)-beta treatment and review nine further cases of systemic sclerosis (SSc) in MS from the literature. Of all 12 patients reported, eight had limited cutaneous SSc, three had diffuse cutaneous SSc and one patient had an antisynthetase syndrome. Localised scleroderma such as morphoea was not described. The mean age at diagnosis was 25.2 years for MS (range 12 to 51) and 38.3 years for SSc (range 16 to 66). Eleven patients developed SSc after the onset of MS and manifested with skin sclerosis after a mean of 14.9 years (range 1 to 45). In five patients IFN-beta was commenced before the development of skin sclerosis (mean 4.6 years, range 1 to 8 years). There was no relationship between the onset of skin sclerosis and MS activity. With the exception of one individual, all patients had antinuclear antibodies. Sclerosing skin disorders may develop in the course of MS. The relatively early age of SSc onset in patients with MS suggests a genetic predisposition and/or an IFN-associated trigger.

Citations

Jul 7, 2015·International Journal of Molecular Sciences·Annette Kolb-MäurerMathias Mäurer
May 24, 2008·Immunology Letters·Luiz Felipe Leomil CoelhoErna Geessien Kroon
Feb 24, 2010·The Journal of Dermatology·Yoshihide Asano
Feb 3, 2016·Experimental Dermatology·Dana SaadehOssama Abbas
Apr 18, 2012·Experimental Dermatology·Mehran GhoreishiJan P Dutz
Jul 20, 2019·The British Journal of Dermatology·E PetersonA G Franks
Nov 25, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jessica L Turnier, J Michelle Kahlenberg
Jun 13, 2021·Autoimmunity Reviews·Clio P MavraganiMaria-Eleftheria Evangelopoulos
Sep 25, 2010·Autoimmunity Reviews·P DieudéY Allanore

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