Sclerostin Antibody Treatment Enhances Rotator Cuff Tendon-to-Bone Healing in an Animal Model

The Journal of Bone and Joint Surgery. American Volume
Shivam A ShahStavros Thomopoulos

Abstract

Rotator cuff tears are a common source of pain and disability, and poor healing after repair leads to high retear rates. Bone loss in the humeral head before and after repair has been associated with poor healing. The purpose of the current study was to mitigate bone loss near the repaired cuff and improve healing outcomes. Sclerostin antibody (Scl-Ab) treatment, previously shown to increase bone formation and strength in the setting of osteoporosis, was used in the current study to address bone loss and enhance rotator cuff healing in an animal model. Scl-Ab was administered subcutaneously at the time of rotator cuff repair and every 2 weeks until the animals were sacrificed. The effect of Scl-Ab treatment was evaluated after 2, 4, and 8 weeks of healing, using bone morphometric analysis, biomechanical evaluation, histological analysis, and gene expression outcomes. Injury and repair led to a reduction in bone mineral density after 2 and 4 weeks of healing in the control and Scl-Ab treatment groups. After 8 weeks of healing, animals receiving Scl-Ab treatment had 30% greater bone mineral density than the controls. A decrease in biomechanical properties was observed in both groups after 4 weeks of healing compared with healthy ...Continue Reading

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Citations

Jun 8, 2018·Connective Tissue Research·Elisabeth A LemmonMegan L Killian
Aug 15, 2018·The Journal of Bone and Joint Surgery. American Volume·Kathleen A DerwinStavros Thomopoulos
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Apr 3, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Tao ZhangHongbin Lu
Sep 17, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Hongbin LuJianzhong Hu
Jul 3, 2021·International Journal of Molecular Sciences·Lanlan Zhang, Chunyi Wen
May 18, 2021·The American Journal of Sports Medicine·Junjie XuJinzhong Zhao

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