Sclerostin in chronic kidney disease-mineral bone disorder think first before you block it!

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Vincent BrandenburgNadine Kaesler

Abstract

Canonical Wnt signalling activity is a major player in physiological and adaptive bone metabolism. Wnt signalling is regulated by soluble inhibitors, with sclerostin being the most widely studied. Sclerostin's main origin is the osteocyte and its major function is blockade of osteoblast differentiation and function. Therefore, sclerostin is a potent inhibitor of bone formation and mineralization. Consequently, blocking sclerostin via human monoclonal antibodies (such as romosozumab) represents a promising perspective for the treatment of (postmenopausal) osteoporosis. However, sclerostin's physiology and the effects of sclerostin monoclonal antibody treatment are not limited to the skeleton. Specifically, the potential roles of sclerostin in chronic kidney disease (CKD) and associated pathologies covered by the term chronic kidney disease and mineral bone disorder (CKD-MBD), which also includes accelerated cardiovascular calcification, warrant specific attention. CKD-MBD is a complex disease condition in which sclerostin antibodies may interfere at different levels and influence the multiform interplay of hyperparathyroidism, renal osteodystrophy and vascular calcification, but the clinical sequelae remain obscure. The present ...Continue Reading

References

Nov 25, 2003·The EMBO Journal·David G WinklerJohn A Latham
Jun 11, 2005·Bone·Hansjoerg Keller, Michaela Kneissel
Jan 15, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hans A Kestler, Michael Kühl
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ina KramerMichaela Kneissel
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Michael S OminskyChris Paszty
Dec 18, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Daniel CejkaHartmut H Malluche
Jan 22, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lynda F Bonewald
Oct 29, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Kelly E BeazleyMaria V Nurminskaya
Nov 15, 2011·Gene·David G MonroeJennifer J Westendorf
Apr 12, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yves SabbaghSusan C Schiavi
Jun 23, 2012·Endocrine Reviews·Hua Zhu KeMichael S Ominsky
Aug 21, 2012·Trends in Endocrinology and Metabolism : TEM·K MarinouM Koutsilieris
Sep 29, 2012·Bone·Teresita BellidoPaola Divieti Pajevic
Oct 2, 2012·Journal of Nephrology·Jorge B Cannata-AndíaCarlos Gómez Alonso
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rafael KramannRebekka K Schneider
Jan 25, 2013·The Biochemical Journal·Wantae KimEek-hoon Jho
Feb 8, 2013·Nature Medicine·Roland Baron, Michaela Kneissel
Feb 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Solenne PelletierDenis Fouque
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zachary C RyanRajiv Kumar
Aug 31, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Thilo KrügerRalf Westenfeld
Jan 3, 2014·The New England Journal of Medicine·Michael R McClungHenry G Bone
Mar 1, 2014·Journal of the American Society of Nephrology : JASN·Yifu FangKeith A Hruska
Apr 25, 2014·The New England Journal of Medicine·Michael R McClung, Andreas Grauer
Apr 25, 2014·The New England Journal of Medicine·Pieter EvenepoelVincent Brandenburg
May 6, 2014·The Lancet. Diabetes & Endocrinology·Marc G VervloetUNKNOWN CKD-MBD Working Group of ERA-EDTA
Sep 25, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christiane DrechslerUNKNOWN NECOSAD Study Group
Nov 20, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sharon M MoeMatthew R Allen
Feb 3, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Timur A YorganThorsten Schinke
Mar 5, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vincent M BrandenburgPieter Evenepoel
Nov 1, 2016·The New England Journal of Medicine·Felicia CosmanAndreas Grauer
Oct 21, 2016·Bone·Antoon H van LieropSocrates E Papapoulos
Jan 8, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Smriti Murali KrishnaJonathan Golledge
Apr 12, 2017·Kidney International·Hirotaka KomabaBeate Lanske
Apr 14, 2017·Journal of Nephrology·Ziad Massy, Tilman Drueke
Sep 12, 2017·The New England Journal of Medicine·Kenneth G SaagAndreas Grauer
Oct 20, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pierre DelanayeEtienne Cavalier

❮ Previous
Next ❯

Citations

Sep 18, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Giuseppe CiancioloMario Cozzolino
Apr 28, 2019·International Journal of Molecular Sciences·Hung-Wei LiaoKuen-Jer Tsai
May 6, 2020·International Journal of Molecular Sciences·Annelies De MaréAnja Verhulst
Sep 24, 2020·International Journal of Molecular Sciences·Chia-Yu HsuKuo-Hu Chen
Jan 6, 2021·Calcified Tissue International·Jordi BoverCarlos Gómez-Alonso
Nov 12, 2020·Cells·Jana HolmarSetareh Orth-Alampour
Feb 16, 2021·Calcified Tissue International·Natalia Carrillo-LópezUNKNOWN European Renal Osteodystrophy (EUROD) Workgroup
Mar 29, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael Pazianas, Paul D Miller
Mar 30, 2021·Frontiers in Endocrinology·Jialiang S WangMarc N Wein
Jul 20, 2021·Frontiers in Immunology·Di WuRajeev Aurora

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Vincent BrandenburgPieter Evenepoel
The New England Journal of Medicine
Michael R McClungHenry G Bone
Nihon rinsho. Japanese journal of clinical medicine
Yasuhiro Hamada, Masafumi Fukagawa
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Wei Ling LauCecilia M Giachelli
© 2022 Meta ULC. All rights reserved