Sclerostin is expressed in the atherosclerotic plaques of patients who undergoing carotid endarterectomy

Diabetes/metabolism Research and Reviews
Gaetano LetoRaffaella Buzzetti

Abstract

Sclerostin (SC) is a monomeric glycoprotein expressed by osteocytes that affects bone formation. Recent studies have suggested a potential role for this protein in the pathophysiology of vascular diseases. The aim of the present study was to investigate SC expression in atherosclerotic plaques of patients affected by severe atherosclerotic disease who underwent carotid endarterectomy. We also evaluated possible differences in SC expression between patients with and without type 2 diabetes (T2D). This was a cross-sectional study involving 46 patients aged 55 to 80 years (mean, 71.1 ± 6.7 years, 36 men, 15 patients with T2D) who underwent carotid endarterectomy. Immunohistochemical levels of SC were evaluated in the atherosclerotic plaques by double-staining immunochemistry, and serum SC levels were evaluated by enzyme-linked immunosorbent assay. Sclerostin was present in the atherosclerotic plaques of all subjects investigated and increased significantly in the media compared with the intima (P < 0.0001) as well as in vascular smooth muscle cells (VSMCs) compared with the infiltrating macrophages (P < 0.0001). However, no significant difference in SC expression was observed between patients with and without T2D. No correlation w...Continue Reading

References

May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Feb 28, 2002·Circulation Research·Xiaohong WangJennifer L Hall
Sep 30, 2009·Nature Reviews. Cardiology·Nikolaos Alexopoulos, Paolo Raggi
Aug 10, 2010·Core Evidence·Angelo L Gaffo, Kenneth G Saag
Aug 16, 2011·Current Opinion in Lipidology·Aikaterini TsaousiSarah J George
Oct 28, 2011·The Journal of Clinical Endocrinology and Metabolism·Antonia García-MartínManuel Muñoz-Torres
Jan 5, 2013·Diabetes Care·Sonia Morales-SantanaManuel Muñoz-Torres
Jun 22, 2013·The Journal of Clinical Endocrinology and Metabolism·Kathleen J ClaesPieter Evenepoel
Oct 1, 2013·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Yi-jun ZhouYin-si Tang
Nov 15, 2013·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Agostino GaudioCarmelo E Fiore
Jan 1, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Gaetano LanzaGian Franco Gensini
Mar 26, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Linda L Demer, Yin Tintut
Apr 2, 2014·Therapeutic Advances in Musculoskeletal Disease·E Michael Lewiecki
May 31, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Renu VirmaniKenichi Sakakura
Sep 23, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Séverine EvrardUNKNOWN SFBC/SN joined working group on vascular calcifications
Jan 27, 2015·Atherosclerosis·Allison L KuipersJoseph M Zmuda
Feb 12, 2015·Reviews in Endocrine & Metabolic Disorders·Maryam SharifiE Michael Lewiecki
Jun 18, 2015·Kidney International·Pieter EvenepoelVincent Brandenburg
Oct 8, 2016·BMC Cardiovascular Disorders·Christian FreiseUwe Querfeld
Feb 10, 2017·Calcified Tissue International·Andrea PalermoNicola Napoli
Mar 25, 2017·Molecular Medicine Reports·Agostino GaudioCarmelo Erio Fiore
Jul 21, 2017·Current Opinion in Lipidology·Austin Gay, Dwight A Towler

❮ Previous
Next ❯

Citations

Oct 11, 2019·Diabetes/metabolism Research and Reviews·Luca D'OnofrioRaffaella Buzzetti
Mar 17, 2020·Journal of the American Heart Association·Gerhard KlingenschmidPeter Willeit
May 6, 2020·International Journal of Molecular Sciences·Annelies De MaréAnja Verhulst
Jul 10, 2020·International Journal of Molecular Sciences·Antonino CatalanoFrancesco Corica
Mar 31, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gill HoldsworthGerard Pasterkamp
Mar 31, 2021·Atherosclerosis·Zachary M ZigmondRoberto I Vazquez-Padron

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Carotid Artery Diseases

Carotid artery disease is a group of pathological conditions of the carotid artery. Discover the latest research on carotid artery disease here.