Sclerotherapy versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis.

The Cochrane Database of Systematic Reviews
Daniela GattiniJuan Cristóbal Gana

Abstract

Portal hypertension commonly accompanies advanced liver disease and often gives rise to life-threatening complications, including bleeding (haemorrhage) from oesophageal and gastrointestinal varices. Variceal bleeding commonly occurs in children with chronic liver disease or portal vein obstruction. Therefore, prevention is important. Primary prophylaxis of variceal bleeding in adults is the established standard of care because of the results of numerous randomised clinical trials demonstrating the efficacy of non-selective beta-blockers or endoscopic variceal ligation in decreasing the incidence of variceal bleeding. In children, band ligation, beta-blockers, and sclerotherapy have been proposed as alternatives for primary prophylaxis of oesophageal variceal bleeding. However, it is unknown whether those treatments are of benefit or harm when used for primary prophylaxis in children. To assess the benefits and harms of sclerotherapy compared with sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis. We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, CENTRAL, PubMed, Embase Elsevier, and two other registers in Feb...Continue Reading

References

Jul 7, 1988·The New England Journal of Medicine·T SauerbruchG Paumgartner
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Feb 15, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P S KamathW R Kim
Aug 7, 2001·The Journal of Pediatrics·D MigaF M Karrer
Aug 2, 2002·Transplantation·Sue V McDiarmidUNKNOWN Principal Investigators and Institutions of the Studies of Pediatric Liver Transplantation (SPLIT) Research Group
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Dec 17, 2003·Journal of Pediatric Gastroenterology and Nutrition·Y ErogluE M Alonso
Dec 25, 2003·Journal of Pediatric Surgery·L W Ernest van HeurnPaul K H Tam
Apr 21, 2004·International Journal of Technology Assessment in Health Care·Pamela Royle, Ruairidh Milne
Aug 31, 2007·The American Journal of Gastroenterology·Guadalupe Garcia-TsaoUNKNOWN Practice Parameters Committee of American College of Gastroenterology
Dec 18, 2007·Journal of Clinical Epidemiology·Jørn WetterslevChristian Gluud
Mar 1, 2008·Gastrointestinal Endoscopy·Mathieu DuchéOlivier Bernard
Apr 26, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoRoberto J Groszmann
Oct 1, 2008·International Journal of Epidemiology·Kristian ThorlundChristian Gluud
Jan 21, 2009·Gastrointestinal Endoscopy·Christine RivetAlain Lachaux
Jan 1, 2010·BMC Medical Research Methodology·Jørn WetterslevChristian Gluud
Oct 12, 2010·Current Gastroenterology Reports·Elizabeth Mileti, Philip Rosenthal
Feb 22, 2011·Journal of Pediatric Gastroenterology and Nutrition·Simon C LingBenjamin L Shneider
May 20, 2011·Journal of Pediatric Gastroenterology and Nutrition·Juan Cristóbal GanaSimon C Ling
Sep 20, 2011·Gastroenterology·Juan Cristóbal GanaSimon C Ling
Mar 14, 2012·Pediatric Transplantation·Benjamin L ShneiderUNKNOWN expert panel of the Children's Hospital of Pittsburgh of UPMC
Apr 19, 2012·JAMA : the Journal of the American Medical Association·UNKNOWN Methodology Committee of the Patient-Centered Outcomes Research Institute (PCORI)
May 23, 2012·Journal of Pediatric Gastroenterology and Nutrition·Hanna LampelaMikko P Pakarinen
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Lise Lotte Gluud, Aleksander Krag
Aug 21, 2012·Journal of Pediatric Gastroenterology and Nutrition·Benjamin L ShneiderUNKNOWN Childhood Liver Disease Research and Education Network
Dec 30, 2014·Journal of Pediatric Gastroenterology and Nutrition·Hanaa M El-KaraksyMortada El-Shabrawi
Sep 12, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin L ShneiderGeorge V Mazariegos
Oct 28, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Guadalupe Garcia-TsaoJaime Bosch
Nov 2, 2016·Journal of Pediatric Gastroenterology and Nutrition·Odile Jeanniard-MaletAlexandre Fabre
Feb 17, 2017·The Cochrane Database of Systematic Reviews·Andreas LundhLisa Bero
Mar 8, 2017·BMC Medical Research Methodology·Jørn WetterslevChristian Gluud
Dec 7, 2017·World Journal of Gastroenterology : WJG·Way Seah LeeRuey Terng Ng
Jun 1, 2018·Journal of Pediatric Gastroenterology and Nutrition·Marta Carneiro de MouraSimon C Ling
Sep 30, 2018·Clinics in Liver Disease·Catherine A Chapin, Lee M Bass
Mar 29, 2019·Journal of Pediatric Gastroenterology and Nutrition·Noelle H EbelKaren F Murray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.