Sclerotiamide: a new member of the paraherquamide class with potent antiinsectan activity from the sclerotia of Aspergillus sclerotiorum

Journal of Natural Products
A C WhyteP F Dowdw

Abstract

Sclerotiamide (1), a new fungal natural product related to the paraherquamides, was isolated by bioassay-guided fractionation of antiinsectan organic extracts from the sclerotia of Aspergillus sclerotiorum (NRRL 5167). The structure was determined primarily through 1H-NMR, 13C-NMR, HMQC, and HMBC experiments. Sclerotiamide causes significant mortality and unusual physiological effects in dietary assays against the corn earworm Helicoverpa zea.

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Citations

Dec 23, 2011·Journal of the American Chemical Society·Shengying LiDavid H Sherman
Apr 3, 2010·The Journal of Organic Chemistry·Jennifer M Finefield, Robert M Williams
Apr 17, 2012·Journal of Natural Products·Jennifer M FinefieldRobert M Williams
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