SCN- ions induce contraction of vascular muscle from male but not female rats

European Journal of Pharmacology
A M ZhangB M Altura

Abstract

It has been suggested that anions may play important roles in the regulation of membrane potentials, intracellular calcium and pH of vascular smooth muscle. It is, thus, possible that anions may be important in the sex-linked differences observed in contractile functions of vascular smooth muscle. With this in mind, we investigated the influence of alteration of the anionic environment, i.e., Cl- chloride ions, on the contractile activity of isolated aortic strips and rings from sexually mature male and female rats. After a few minutes of changing the incubation medium from normal chloride-containing Krebs-Ringer bicarbonate (NKRB) to a SCN- (thiocyanate) modified Krebs-Ringer bicarbonate solution (SCN-KRB; 118 mM SCN- substituted for 118 mM Cl-), resting tension increased dramatically, e.g., to about 85% of KCl maximum in males, but not in females. This increased resting tension could not be inhibited or attenuated by specific adrenergic, cholinergic, histaminergic, serotoninergic or cyclo-oxygenase inhibitors. Likewise use of a local anesthetic in high concentration (i.e., procaine HCl, 10(-3) M) also failed to inhibit or attenuate the SCN(-)-induced contractions. However, use of 5 mM EGTA, incubation in Ca2(+)-free SCN-KRB m...Continue Reading

References

Jul 1, 1979·Pflügers Archiv : European journal of physiology·K E Kamm, R Casteels
Apr 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·B M Altura, B T Altura
May 1, 1987·Journal of Molecular and Cellular Cardiology·N Sperelakis
Jul 1, 1986·Stroke; a Journal of Cerebral Circulation·L R CaplanD B Hier
Jun 1, 1987·Pflügers Archiv : European journal of physiology·F P GerstheimerV A Kreye
Oct 1, 1973·Canadian Journal of Physiology and Pharmacology·E R Anderson, J G Foulks
Mar 1, 1974·Microvascular Research·B M Altura, B T Altura
Jul 1, 1967·Canadian Journal of Physiology and Pharmacology·K H Jhamandas, C W Nash
Feb 1, 1983·The Journal of General Physiology·J A DaniB Hille
Sep 24, 1981·European Journal of Pharmacology·P D TurlapatyB M Altura
Apr 1, 1957·Journal of Cellular and Comparative Physiology·M LUBIN

❮ Previous
Next ❯

Citations

Aug 1, 1991·Naunyn-Schmiedeberg's Archives of Pharmacology·A M ZhangB M Altura
Oct 15, 1991·European Journal of Pharmacology·A ZhangB M Altura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.